Xin Xu

ORCID: 0000-0002-8323-6363 · 11 papers in corpus
nonrandomized-trial 2026
Frontiers in cell and developmental biology ·doi:10.3389/fcell.2026.1746912

RESEARCH QUESTION: Embryo quality serves as a pivotal determinant in assisted reproductive technology (ART) outcomes, with high-grade embryos correlating with improved pregnancy/live birth rates but poor morphology elevating the risks of im…

observational 2026
Eco-Environment & Health ·doi:10.1016/j.eehl.2026.100253

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with potential reproductive toxicity, yet their profiles in follicular fluid and impacts on human fertility remain unclear. Given the importance of diet as…

lab-animal 2025
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2510060122

Pregnancy requires a supportive uterine environment facilitated by steroid hormone-regulated differentiation of endometrial stromal fibroblasts into decidual cells and tight control of inflammation. Serum response factor (SRF) is a widely e…

observational 2023
Frontiers in endocrinology ·doi:10.3389/fendo.2023.1315099

INTRODUCTION: Female infertility is defined as the absence of clinical pregnancy after 12 months of regular unprotected sexual intercourse. METHODS: This study employed metabolomics and proteomics approaches to investigate the relationship…

lab-animal 2023
Frontiers in endocrinology ·doi:10.3389/fendo.2023.1279610

OBJECTIVE: The purpose of this study was to explore the effect of removal of different volumes of ovarian tissue on fertility and offspring development of SD rats. METHODS: SD rats were randomly divided into 6 groups according to different…

rct 2023
Frontiers in endocrinology ·doi:10.3389/fendo.2023.1168175

OBJECTIVE: The aim of this study is to optimize the treatment methods of infertility, which is suggested to be mainly caused by thin endometrium, using a special form of traditional Chinese medicine, the Dingkun pill (DKP), to increase the …

lab-animal 2023
iScience ·doi:10.1016/j.isci.2023.107616

WNK1 is an important regulator in many physiological functions, yet its role in male reproduction is unexplored. In the male germline, WNK1 is upregulated in preleptotene spermatocytes indicating possible function(s) in spermatogenic meiosi…

lab-animal 2022
Evidence-based complementary and alternative medicine : eCAM ·doi:10.1155/2022/5256578

The objective of this study is to observe the effect of relieving pain of Huayu Sanjie enema liquid (HYSJ-EL) on endometriosis model rats and to explore its mechanism of action. Of 24 female Sprague Dawley rats, six were randomly selected a…

nonrandomized-trial 2021
Frontiers in endocrinology ·doi:10.3389/fendo.2021.725202

OBJECTIVE: To investigate the effect of two treatments on the outcome of freeze-thaw embryo transfer for pregnancy assistance in thin endometrium. METHODS: A retrospective study was conducted on 66 patients who failed in the first cycle tr…

observational 2021
BMC pregnancy and childbirth ·doi:10.1186/s12884-021-04202-9

BACKGROUND: Psychological distress may exert a negative influence on reproductive function of couples at reproductive age. Couples seeking assisted reproductive technology (ART) treatment may have a higher prevalence of psychological distre…

rct 2020
·doi:10.35841/0970-938x.31.6.155-163

Honghuaruyi (HHRY) pill is considered as an effective treatment for Chronic pelvic pain (CPP) with the efficacy of promoting qi and blood circulation but lack of high-quality clinical evidence. This study is to evaluate the efficacy and saf…