Jean‐Michel Foidart

Bleeding irregularities are one of the major reasons for discontinuation of oral contraceptives (OCs), and therefore clinicians need to set expectations during consultations. In this review we provide an overview of bleeding data of recentl…

Deep infiltrating endometriosis (DIE) responds variably to hormonal therapy. Mutations in cancer driver genes have been identified in a fraction of the ectopic endometrial epithelial cells, suggesting a functional heterogeneity of these les…

BACKGROUND: Endometrial cells, which are shed by retrograde menstruation, may aberrantly express molecules involved in invasion and migration, leading to endometriosis. The aim of this study was to investigate the expression of the laminin …

Selective progesterone receptor modulators (SPRM) represent a new class of synthetic steroids, which can interact with the progesterone receptor (PR) and can exert agonist, antagonist or mixed effects on various progesterone target tissues …

peer reviewed

BACKGROUND/AIMS: The aim of this study was to induce endometriosis in female rhesus macaques (Macaca mulatta) for research purposes. METHODS: Three female monkeys from 4 to 4.5 years of age underwent three consecutive attempts at endometri…

Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynaecological history and a careful clinical examination…

Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynecological history and a careful clinical examination …

The transplantation theory, proposed by Sampson in 1927, involves the dissemination of viable epithelial and stromal endometrial cells via the fallopian tubes into the abdominal cavity and the implantation of these cells into the peritoneum…

OBJECTIVE: To evaluate whether endometriosis could be related to an impaired balance between apoptosis and proliferation, two processes which could be modulated by hormonal status. DESIGN: Immunohistochemical study. SETTING: Academic rese…

OBJECTIVE: To evaluate, in a new original in vitro assay, putative factors that could modulate the adhesion of endometrial cells to peritoneum. DESIGN: Prospective, controlled in vitro study. SETTING: Academic research laboratory. PATIEN…

peer reviewed

In the past, the treatment of benign uterine lesions required, in many instances, a hysterectomy. These days, most cases can be successfully treated by hysteroscopy. To be reliable, this technique must lead to a significant reduction in the…

ObjectiveTo compare the localization of adhesion proteins (laminin and fibronectin) and their receptors of the integrin family in endometriosis and endometrium.DesignAn immunohistochemical study.SettingUniversity Hospital, Department of Gyn…