Bert W. O’Malley

ORCID: 0000-0003-3332-1399 · 9 papers in corpus · active 2010-2024

Study types

  • article 6
  • book-chapter 1
  • other 1
  • review 1

Condition tags

  • endometriosis 8
  • mesh:D004715 6
  • infertility 1
other 2024
A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis
Nature communications ·doi:10.1038/s41467-024-46180-4

Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor's transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums fo…

article 2019
Genomic Function of Estrogen Receptor β in Endometriosis
Endocrinology ·doi:10.1210/en.2019-00442

Estrogen receptor (ER) β plays a critical role in endometriosis progression because cytoplasmic ERβ stimulates proinflammatory signaling in ectopic lesions and prevents apoptosis to promote their survival. However, the role of "nuclear ERβ"…

article 2018
Bufalin suppresses endometriosis progression by inducing pyroptosis and apoptosis
·doi:10.1530/joe-17-0700

The steroid receptor coactivator (SRC)-1 isoform/estrogen receptor (ER)-β axis has an essential role in endometriosis progression. In this context, therefore, bufalin was employed as a ‘tool compound’ to evaluate inhibitors of SRC in altern…

article 2018
The pathogenic role of estrogen receptor beta drives in endometriosis
·doi:10.1530/endoabs.54.oc5

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

article 2015
Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis
Cell ·doi:10.1016/j.cell.2015.10.034
article 2015
The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety
Molecular pharmacology ·doi:10.1124/mol.115.100925
review 2014
The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis
Human reproduction update ·doi:10.1093/humupd/dmu002

BACKGROUND: Endometriosis is defined as the colonization and growth of endometrial tissue at anatomic sites outside the uterine cavity. Up to 15% of reproductive-aged women in the USA suffer from painful symptoms of endometriosis, such as i…

article 2012
A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis
Nature medicine ·doi:10.1038/nm.2826
book-chapter 2010
Pathogenesis of Endometriosis through Matrix Metalloproteinase -9 Mediated Steroid Receptor Coactivators-1 Isoform Formation.
·doi:10.1210/endo-meetings.2010.part3.p8.p3-361