Jiang T

Uterine corpus endometrial carcinoma (UCEC) ranks as the 6th most common malignancy among women. Emerging evidence indicates that the dysregulation of tRNA-derived fragments (tRFs) is involved in the pathogenesis of multiple cancer types, i…

BACKGROUND: The relationship between preimplantation hematological profiles and clinical pregnancy rates following frozen embryo transfer (FET) has not been thoroughly investigated. METHODS: A retrospective study was conducted. Participant…

The aim of this study was to detect circulating tumor cells (CTCs) in the peripheral blood of patients with cholangiocarcinoma (CCA) using a CTCs sorting technique and to assess the association between CTC counts and patient prognosis. Epit…

BACKGROUND: Assisted reproductive technologies (ART) have been proven to be associated with the increased risk of pregnancy complications such as gestational hypertension and neonatal disorders, which may have negative effects on offspring'…

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with potential reproductive toxicity, yet their profiles in follicular fluid and impacts on human fertility remain unclear. Given the importance of diet as…

BACKGROUND: Mast cells (MCs) are pivotal immune cells. Beyond soluble mediators, mast cell-derived extracellular vesicles (MC-EVs) are crucial for intercellular communication. MC-EV heterogeneity, influenced by cellular activation and micro…

De novo mutations (DNMs) are an important source of congenital diseases. With delayed parenthood and assisted reproductive technology (ART) use increasing, it is essential to elucidate how these reproductive factors influence DNMs and wheth…

BACKGROUND: This study aims to use non-targeted metabolomics to analyze the metabolic characteristics of follicular fluid in patients with decreased ovarian reserve (DOR) and explore the mediating role of these metabolites in DOR and assist…

This study aimed to delineate the molecular profile underlying progesterone resistance in atypical endometrial hyperplasia (AEH), a precancerous condition associated with a high risk of malignant transformation. Using a retrospective cohort…

Endometriosis is a common gynecological disease that can cause pelvic adhesions. Severe adhesions increase the difficulty of surgery, resulting in prolonged operation time, increased intraoperative bleeding, and increased complications such…

PURPOSE: Infants born after assisted reproductive technology (ART) have more adverse health outcomes than spontaneously conceived infants. Evidence on the impact of ART on the offspring's visual system, particularly refractive errors (REs),…

BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 diabetes mellitus (T2DM), and the risk of PCOS increases in patients with T2DM of reproductive age. The bidirectional link between PCOS and T2DM has…

Gynecologic diseases, including infectious disorders, endocrine-related conditions, gynecologic malignancies, and pregnancy complications, are clinically diverse yet frequently share features of hormonal imbalance, microbial dysbiosis, and …

Advanced maternal age is associated with adverse pregnancy outcomes. However, the impact of changes in maternal physiology, biochemistry, vaginal microbiome, and its metabolites related to reproductive age on pregnancy outcomes is uncertain…

Intravenous leiomyomatosis (IVL) is a rare benign tumor originating from the smooth muscle of the uterus. Tumor cells spread along the veins, which may involve the uterine veins, pelvic veins, inferior vena cava, and even the right atrium. …

As an emerging endocrine-disrupting agent and structural analog of bisphenol A (BPA), bisphenol B (BPB) raises significant concerns due to its potential to induce male reproductive toxicity. Despite its presence in maternal bodily fluids, t…

Female adnexal malignancies, while relatively uncommon, exhibit high mortality rates due to often-late diagnosis. The serine/threonine kinase 11 (STK11) is a tumor suppressor gene, and its inactivation or mutation often leads to an autosoma…

ObjectiveTo use self-reported preconception data to derive models that predict the risk of miscarriage.DesignProspective preconception cohort study.SettingNot applicable.PatientsStudy participants were female, aged 21-45 years, residents of…

ETHNOPHARMACOLOGICAL RELEVANCE: Shrub kava has long been grown and utilized, primarily in the South Pacific region, for ceremonial, religious, and social occasions. It has been used as a pain reliever and muscle relaxant in medicinal practi…

Endometriosis is a hormone-dependent inflammatory disease characterized by the existence of endometrial tissues outside the uterine cavity. Pharmacotherapy and surgery are the current dominant management options for endometriosis. The great…

Tao Jiang,1,* Yuan Chen,1,* Xia Gu,1,2 Mengyue Miao,1 Daifeng Hu,1 Hui Zhou,1 Jing Chen,3 Alexander Tobias Teichmann,1 Youzhe Yang1,2 1Sichuan Provincial Center for Gynaecology and Breast Diseases, The Affiliated Hospital of Southwest Medic…

STUDY QUESTION: Can we derive adequate models to predict the probability of conception among couples actively trying to conceive? SUMMARY ANSWER: Leveraging data collected from female participants in a North American preconception cohort s…

Endometriosis is an estrogen-dependent inflammatory gynecological disorder that is pathologically defined as the growth of endometrial glands and stroma outside of the uterine cavity. It is estimated that more than 15% of women of reproduct…

BACKGROUND: Early embryonic arrest (EEA) leads to repeated cessation of fresh cycles among infertile women undergoing in vitro fertilization (IVF). Whether the levels of some essential trace elements [copper (Cu), zinc (Zn), selenium (Se) a…

BACKGROUND: Endometriosis affects up to 10 % of women of reproductive age and can lead to infertility. Research investigating whether combined exposure to arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) is related to an increased ris…