Extracellular vesicles (EVs) in the mammalian oviduct constitute a key maternal regulatory system that maintains redox balance during early embryogenesis, yet their molecular cargo and functional relevance in human embryos remain poorly def…
Clinical application of mesenchymal stem cells for endometrial repair has been hampered by variability in cell quality, large-scale production, and uncertainty regarding the optimal delivery route. In this study, we investigated the therape…
Chen Zhang,1 Xinhui Sun,2,3 Conglu Sui,1 Ying Cao4,51Department of Gynecology, Beijing University of Chinese Medicine Affiliated Third Hospital, Beijing, People’s Republic of China; 2Department of Gynecology, The First Teaching Hospital of …
OBJECTIVE: To investigate the effects of Shaofu Zhuyu Decoction on decidualization and the expression of progesterone receptor-β (PR-β) and heterogeneous nuclear ribonucleoprotein L (HNRNPL) in a mouse model of endometriosis. METHODS: An e…
STUDY QUESTION: Do extracellular vesicles (EVs) from human Fallopian tubes exert an influence on early embryo development in vitro? SUMMARY ANSWER: Human Fallopian tube EVs carrying miRNAs increase murine embryo viability in vitro. WHAT I…
BACKGROUND: There is a higher risk of preterm delivery (PTD) in singleton live births conceived after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) compared with spontaneously conceived pregnancies. The objective of o…
OBJECTIVE: To investigate the influence of oviductal extracellular vesicles from patients with endometriosis on early embryo development. DESIGN: In vitro experimental study. SETTING: University-affiliated hospital. PATIENTS: Women with …
PURPOSE: Endometrial extracellular vesicles are essential in regulating trophoblasts' function. This study aims to investigate whether endometrial extracellular vesicles (EVs) from recurrent implantation failure (RIF) patients inhibit the p…
BACKGROUND: Thin endometrium on ovulation triggering day is associated with impaired pregnancy outcomes in women after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), but the role of thick endometrium on pregnancy outcom…