Nikolaos Machairiotis

Implantation failure remains a major challenge in assisted reproductive technology (ART) and is a significant contributor to infertility in women with endometriosis. Beyond mechanical distortion and ovarian dysfunction, increasing evidence …

Background/Objectives: Artificial intelligence (AI) models are increasingly applied across the assisted reproductive technology (ART) workflow, including male-factor assessment, ovarian stimulation, endometrial receptivity evaluation, embry…

Background: Endometriosis is an estrogen-dependent inflammatory disorder that is typically related to infertility, for which assisted reproductive technologies are needed. Fresh embryo transfer can result in hormone levels that are supraphy…

Cellular senescence, mitochondrial dysfunction, and cumulative oxidative stress (OS) are the main causes of the progressive decreases in oocyte and sperm quality that define reproductive age. There is growing evidence that these processes a…

Background/Objectives: Adenomyosis is increasingly being identified in women of childbearing age as a cause of infertility and adverse pregnancy outcomes. As hysterectomies are not suitable for fertile women, conservative surgical managemen…

Isolated fallopian tube torsion (IFTT) is a rare cause of acute pelvic pain that is often misdiagnosed due to its non-specific clinical findings. Early diagnosis and operative intervention are vital for the preservation of fertility. We rep…

Uterine fibroids (leiomyomas) are common benign tumors in women of reproductive age and are often associated with infertility, heavy menstrual bleeding, and pelvic discomfort. Laparoscopic myomectomy (LSM) has emerged as a fertility-preserv…

Poor ovarian response (POR) remains a significant challenge in the field of assisted reproductive technology (ART), as the quantity and quality of oocytes retrieved directly influence embryo implantation, clinical pregnancy, and live birth …

Background: Endometriosis is a benign gynecologic condition that has the risk of malignant transformation in approximately 0.5-1% of cases, most of which develop into endometriosis-associated ovarian cancers (EAOCs), such as clear cell and …

Background:Endometriosis is a disorder in which the presence of endometrial-like tissue is found outside the uterus and affects 5-15% of women. It may undergo malignant transformation, generally presenting with ovarian cancers of endometrio…

The purpose of this prospective case-control study is to investigate the correlation of the miR-143 gene rs353292 polymorphism in Caucasian women with recurrent pregnancy loss (RPL) compared to a matched control group with at least one live…

Background: Endometriosis is characterized by the presence of endometrial tissue outside the uterus. Beyond medical treatment, surgical intervention is also a viable consideration. However, current guidelines do not clearly indicate whether…

BACKGROUND: Indocyanine green (ICG) is an injectable fluorochrome that has recently gained popularity as a means of assisting intraoperative visualization during laparoscopic and robotic surgery. Many systematic reviews and meta-analyses ha…

Background:Endometriosis is characterized by the presence of endometrial tissue outsidethe uterus. Beyond medical treatment, surgical intervention is also a viableconsideration. However, current guidelines do not clearly indicate whetherlap…

BACKGROUND/OBJECTIVES: Embryo implantation is a highly complex process that requires the precise regulation of numerous molecules to be orchestrated successfully. Micro RNAs (miRNAs) are small non-coding RNAs that regulate gene expression a…

Adenomyosis is characterized by ectopic proliferation of endometrial tissue within the myometrium. Histologically, this condition is marked by the presence of islands of benign endometrial glands surrounded by stromal cells. The myometrium …

BACKGROUND: Glutathione S-transferase (GST) M1 belongs to a family of detoxification enzymes and deficiency in enzyme activity is due to a homozygous deletion of the GSTM1 gene. Several studies reveal a possible correlation between female i…

Ovarian cancer is a malignant disease that affects thousands of patients every year. Currently, we use surgical techniques for early-stage cancer and chemotherapy treatment combinations for advanced stage cancer. Several novel therapies are…

OBJECTIVES: Isolated ovarian agenesis in the absence of Mullerian duct anomalies are rare events which are usually discovered after menarche and incidentally in the context of an intervention for other indications, such as laparoscopy or as…

The presence of ascites is a common clinical presentation in gynecologic oncology patients. Hemorrhagic ascites (HA) due to endometriosis is a rare presentation that can be easily misdiagnosed as ovarian malignancies. The present study aims…

The objective of this review is to describe the effectiveness of laparoscopy in the diagnosis and treatment of pelvic congestion syndrome (PCS). PCS is a cause of chronic pelvic pain (CPP) and is associated with dysfunction of the pelvic ve…

BACKGROUND: pain is one of the main symptoms of endometriosis and it has a deleterious effect on a patients' personal and social life. To date, the clinical management of pain includes prolonged medication use and, in some cases, surgery, b…