Nathalie Lédée

BACKGROUND: The endometrial immune environment regulates maternal immune tolerance and plays a key role in embryo implantation. We investigated whether its impact on reproductive outcomes differs between fresh and frozen embryo transfer (FE…

INTRODUCTION: A balanced endometrial immune profile is considered to be the ideal environment for a successful implantation, as opposed to endometrial immune dysregulation. However, the embryo quality may be the pivotal 'immune' factor comp…

INTRODUCTION: Despite advancements in assisted reproductive treatments, 70% of transferred embryos fail to implant successfully, yielding significant personal and global repercussions. One promising avenue of research is to take into accoun…

Assisted reproductive technologies (ART) are now widely recognized as a key therapeutic option for individuals experiencing infertility. Despite these technological improvements, ART success rates remain suboptimal. One emerging area of int…

INTRODUCTION: The endometrial immune profiling is an innovative approach based on the analysis of the local immune reaction occurring in the endometrium at the time of the embryo implantation. By documenting the local immune activation duri…

Poor endometrial development during in vitro fertilization remains challenging. Indeed, no broadly accepted definition of poor endometrial development exists, and no treatment has shown any improvement in the condition. The aim of this stud…

The uterine luminal environment was explored with regard to interleukin-18 (IL-18) and mannose-binding lectin (MBL) and the possibility that the procedure of flushing the uterine cavity would optimize the physiological initial pseudo-inflam…

PROBLEM: Cytokines are obviously very important in an established pregnancy, but what about human embryo implantation? METHODS: Literature review. RESULTS: We first discuss the necessity and limits of animal models, and then review the fe…

Ureteral endometriosis is a rare but serious entity because of its insidious evolution which can lead to the loss of kidney function. Three cases are reported: two patients have received a medical and endoscopic management and the third one…