Le Zhang

ORCID: 0000-0002-3708-1727 · 4 papers in corpus
review 2026
Involvement of the pyroptosis-HMGB1 axis in systemic diseases
Frontiers in cell and developmental biology ·doi:10.3389/fcell.2026.1814812

Pyroptosis is a lytic form of regulated cell death driven by inflammasome activation and gasdermin-mediated membrane rupture, characterized by robust inflammatory amplification. High-mobility group box 1 (HMGB1), a multifunctional nuclear p…

lab-animal 2025
The downregulation of FKBP5 contributes to the pathogenesis of adenomyosis and is associated with impaired endometrial receptivity†
Biology of reproduction ·doi:10.1093/biolre/ioaf126

Adenomyosis is characterized by the infiltration of endometrial glands and stroma into the myometrium which affects about 35% women at reproductive age. Women affected by adenomyosis always experience issues such as defective decidualizatio…

lab-animal 2024
Injectable Magnetic Hydrogel Incorporated with Anti-Inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis
Advanced science (Weinheim, Baden-Wurttemberg, Germany) ·doi:10.1002/advs.202409778

Endometriosis is a prevalent gynecological condition characterized by chronic pelvic pain, dysmenorrhea, and infertility, affecting ≈176 million women of reproductive age worldwide. Current treatments, including pharmacological and surgical…

other 2022
Integrated bioinformatics analysis and experimental validation reveals fatty acid metabolism-related prognostic signature and immune responses for uterine corpus endometrial carcinoma
Frontiers in oncology ·doi:10.3389/fonc.2022.1030246

BACKGROUND: Uterine corpus endometrial carcinoma (UCEC) is the third most common gynecologic malignancy. Fatty acid metabolism (FAM) is an essential metabolic process in the immune microenvironment that occurs reprogramming in the presence …