Tohru Kiyono

No ORCID on file · 11 papers in corpus · active 2009-2025

Study types

  • article 7
  • other 3
  • preprint 1

Condition tags

  • endometriosis 9
  • mesh:D004715 5
  • endometrioma 2
  • adenomyosis 1
other 2025
Establishment of a Novel In Vitro and In Vivo Model to Understand Molecular Carcinogenesis of Endometriosis-Related Ovarian Neoplasms
International journal of molecular sciences ·doi:10.3390/ijms26051995

The molecular mechanisms through which endometriosis-related ovarian neoplasms (ERONs) develop from benign endometrioma remain unclear. It is especially a long-standing mystery why ovarian endometrioma has the potential to develop into two …

preprint 2025
Establishment of a Novel In Vitro and In Vivo Model to Understand Molecular Carcinogenesis of Endometriosis-Related Ovarian Neoplasms
·doi:10.20944/preprints202502.0858.v1

The molecular mechanisms through which endometriosis-related ovarian neoplasms (ERONs) develop from benign endometrioma remain unclear. It is especially a long-standing mystery why ovarian endometrioma has the potential to develop into two …

other 2024
Association between KRAS and PIK3CA Mutations and Progesterone Resistance in Endometriotic Epithelial Cell Line
Current issues in molecular biology ·doi:10.3390/cimb46040224

Although endometriosis is a benign disease, it is associated with cancer-related gene mutations, such as KRAS or PIK3CA. Endometriosis is associated with elevated levels of inflammatory factors that cause severe pain. In a previous study, w…

article 2023
Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts

Retrograde menstruation is a widely accepted cause of endometriosis. However, not all women who experience retrograde menstruation develop endometriosis, and the mechanisms underlying these observations are not yet understood. Here, we demo…

other 2023
Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts
Science translational medicine ·doi:10.1126/scitranslmed.add1531

Retrograde menstruation is a widely accepted cause of endometriosis. However, not all women who experience retrograde menstruation develop endometriosis, and the mechanisms underlying these observations are not yet understood. Here, we demo…

article 2021
Establishment of a Novel In Vitro Model of Endometriosis with Oncogenic KRAS and PIK3CA Mutations for Understanding the Underlying Biology and Molecular Pathogenesis
Cancers ·doi:10.3390/cancers13133174

Endometriosis-harboring cancer-associated somatic mutations of PIK3CA and KRAS provides new opportunities for studying the multistep processes responsible for the functional and molecular changes in this disease. We aimed to establish a nov…

article 2020
Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis
F&S science ·doi:10.1016/j.xfss.2020.09.001

Objective To establish and characterize cell lines derived from human endometrial epithelial cells (ECs) and mesenchymal cells (MCs) from patients with and without endometriosis. Design In vitro experimental study. Setting University and na…

article 2019
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations
Nature communications ·doi:10.1038/s41467-019-13708-y

Uterine adenomyosis is a benign disorder that often co-occurs with endometriosis and/or leiomyoma, and impairs quality of life. The genomic features of adenomyosis are unknown. Here we apply next-generation sequencing to adenomyosis (70 ind…

article 2014
Concurrent estrogen action was essential for maximal progestin effect in oral contraceptives
Fertility and sterility ·doi:10.1016/j.fertnstert.2014.02.005
article 2014
Dienogest, a synthetic progestin, down-regulates expression of CYP19A1 and inflammatory and neuroangiogenesis factors through progesterone receptor isoforms A and B in endometriotic cells
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2014.12.008
article 2009
Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression
Molecular human reproduction ·doi:10.1093/molehr/gap042

Dienogest is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. In this study, we examined the direct effects of dienogest on the proliferation of human endometrial …