Christine Huselton

No ORCID on file · 3 papers in corpus
lab-animal 2008
2-phenyl-4-piperazinylbenzimidazoles: orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor
Bioorganic & medicinal chemistry ·doi:10.1016/j.bmc.2008.05.024

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has shown positive clinical results in numerous reproductive tissue disorders such as endometriosis, prostate cancer and others. Traditional therapy has been limited to peptid…

lab-animal 2008
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)
Journal of medicinal chemistry ·doi:10.1021/jm701080t

We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previous…

lab-animal 2008
Development of an early biomarker for the ovarian liability of selective estrogen receptor modulators in rats
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2008.08.008

Selective estrogen receptor modulators (SERMs) have the potential to treat estrogen sensitive diseases such as uterine leiomyoma and endometriosis, which are prevalent in reproductive age women. However, SERMs also increase the risk of deve…