Michael E. DiSanto

review 2025

Basic science and translational research: recommendations from the Fifth International Consultation for Sexual Medicine (ICSM 2024)

Sexual medicine reviews ·doi:10.1093/sxmrev/qeaf032

INTRODUCTION: Sexual function is a critical issue for human health and impacts the quality of life of patients and their partners. In this ICSM report, basic science and translational perspectives have been examined from the past decade of …

lab-animal 2024

Y-27632 targeting ROCK1&2 modulates cell growth, fibrosis and epithelial-mesenchymal transition in hyperplastic prostate by inhibiting β-catenin pathway

Molecular biomedicine ·doi:10.1186/s43556-024-00216-9

Benign prostatic hyperplasia (BPH) is a prevalent condition affecting the male urinary system, with its molecular mechanisms of pathogenesis remaining unclear. Y-27632, a non-isoform-selective Rho kinase inhibitor, has shown therapeutic pot…

observational 2019

077 Comparison of the Actomyosin ATPase Inhibitor Calponin and the Sphingosine-1-phosphate Cell Differentiation Pathway Regulatory Enzymes Sphingosine Kinase 1 and Sphingomyelin Synthase in Vaginal Wall Smooth Muscle of Women with and without Pelvic Organ Pro

·doi:10.1016/j.jsxm.2019.01.088

Pelvic Organ Prolapse (POP) is the descent of the vaginal walls and uterus leading to herniation of nearby organs into the vagina. POP prevalence as reported by patient symptoms is ∼3%, but it has been reported as high as 50% upon physical …