Morrison J — Endo Lab

observational 2025

Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints

Nature communications ·doi:10.1038/s41467-025-58129-2

Metabolites are small molecules that are useful for estimating disease risk and elucidating disease biology. Here, we perform two-sample Mendelian randomization to systematically infer the potential causal effects of 1099 plasma metabolites…

other 2025

Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube

Nature communications ·doi:10.1038/s41467-025-58145-2

The human Fallopian tube (FT) is an important organ in the female reproductive system and has been implicated as a site of origin for pelvic serous cancers, including high-grade serous tubo-ovarian carcinoma (HGSC). We have generated compre…

other 2020

Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth

Science advances ·doi:10.1126/sciadv.abc8696

While a genetic component of preterm birth (PTB) has long been recognized and recently mapped by genome-wide association studies (GWASs), the molecular determinants underlying PTB remain elusive. This stems in part from an incomplete availa…

rct 2001

Pragmatic randomised controlled trial to evaluate guidelines for the management of infertility across the primary care-secondary care interface

BMJ (Clinical research ed.) ·doi:10.1136/bmj.322.7297.1282

OBJECTIVE: To investigate the effect of clinical guidelines on the management of infertility across the primary care-secondary care interface. DESIGN: Cluster randomised controlled trial. SETTING: General practices and NHS hospitals accep…