Akira Hara

No ORCID on file · 3 papers in corpus
review 2020
Molecular Trajectory of BRCA1 and BRCA2 Mutations
Frontiers in oncology ·doi:10.3389/fonc.2020.00361

Every cancer carries genomic mutations. Although almost all these mutations arise after fertilization, a minimal count of cancer predisposition mutations are already present at the time of genesis of germ cells. Of the cancer predisposition…

case-report 2019
High-grade serous ovarian carcinoma with mucinous differentiation: report of a rare and unique case suggesting transition from the "SET" feature of high-grade serous carcinoma to the "STEM" feature
Diagnostic pathology ·doi:10.1186/s13000-019-0781-9

BACKGROUND: High-grade serous carcinoma, a representative high-grade ovarian carcinoma, is believed to be closely associated with a TP53 mutation. Recently, this category of ovarian carcinoma has gained increasing attention owing to the rec…

lab-animal 2007
A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase
Medicinal chemistry (Shariqah (United Arab Emirates)) ·doi:10.2174/157340607782360399

20alpha-hydroxysteroid dehydrogenase (AKR1C1) plays a key role in the metabolism of progesterone and other steroid hormones, thereby regulating their action at the pre-receptor level. AKR1C1 is implicated in neurological and psychiatric con…