Wang L

Bovine viral diarrhea virus (BVDV) is a widespread pathogen causing significant economic losses in cattle. There is an urgent need for drugs to treat BVDV-induced reproductive dysfunction. This study investigated the mechanisms and targets …

BACKGROUND: Ovarian cancer is a major female reproductive health issue with heterogeneous biological features on its subtypes, which may require different therapeutic strategies. Glucagon-like peptide-1 receptor (GLP-1R) agonists were repor…

BACKGROUND: Oocyte aneuploidy is a major cause of pregnancy failure in women of advanced maternal age (AMA), and current assisted reproductive technologies offer limited effective strategies to prevent age-related decline in oocyte quality.…

BACKGROUND: Elevated maternal body mass index (BMI) increases miscarriage risk in assisted reproductive technology, but it is unclear whether this risk differs between singleton and twin pregnancies. Twin gestations impose greater metabolic…

BACKGROUND: Nerve growth factor (NGF), which acts on receptors tropomyosin receptor kinase A and p75 neurotrophic receptor, is a member of neurotrophin family and a kind of secretory polypeptides. METHODS: A comprehensive literature search…

Preoperative misdiagnosis and the adoption of incorrect surgical approaches occur frequently in patients with endometrial stromal tumors (ESTs) because of their rarity, nonspecific clinical manifestations, and imaging features that highly o…

Pelvic organ prolapse (POP) is a prevalent condition that significantly impairs women's quality of life and is closely linked to dysregulated estrogen signaling. This review examines the mechanisms through which estrogen, acting via nuclear…

Endometriosis is a chronic inflammatory disease characterised by pain, infertility and recurrence. Current pharmacological management relies largely on hormonal suppression, which can reduce pain and disease activity but does not eradicate …

OBJECTIVE: Obesity impairs endometrial receptivity; however, the mechanism remains unclear. Obesity is associated with elevated leptin levels, and leptin receptor (Ob-Rb) has been demonstrated to be expressed in the human endometrium, but t…

OBJECTIVES: Nutcracker syndrome (NCS) is an uncommon vascular disease, characterized by anatomical compression of the left renal vein (LRV). Associated symptoms include flank and pelvic pain, as well as hematuria and varicocele. Our objecti…

Persistent organic pollutants (POPs) are a class of chemical substances with environmental persistence, bioaccumulation, and high toxicity, which are widely present in the environment and food chains. Prostate cancer (PCa) is a highly preva…

Clinical application of mesenchymal stem cells for endometrial repair has been hampered by variability in cell quality, large-scale production, and uncertainty regarding the optimal delivery route. In this study, we investigated the therape…

BACKGROUND: Endometriosis (EMs) is an estrogen-dependent chronic inflammatory disease, and its pathogenesis remains unclear. Although the placenta is an organ with tumor-like characteristics, its development, including its invasive function…

OBJECTIVE: The aim of the present study was to analyze pregnancy outcomes among patients diagnosed with first-trimester decidual polyps (DPs) following fresh embryo transfer who underwent expectant management and to further explore risk fac…

Adenomyosis (AM) commonly affects women of reproductive age and can impair female fertility, yet its diagnosis and pathogenesis remain challenging. We compared serum IgG1 Fc‑glycosylation profiles between AM patients (n = 30) and non‑AM con…

BACKGROUND: Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disorder characterized by impaired surfactant clearance due to alveolar macrophage dysfunction. Leuprorelin acetate, a gonadotropin-releasing hormone agonist, is widely us…

INTRODUCTION: This study aimed to examine the impact of quercetin on a mouse model of endometriosis and elucidate its underlying mechanisms. METHODS: An endometriosis model was established using C57BL/6 mice, which were divided into three …

Neuroendocrine neoplasms (NENs) are a rare type of tumor originating from peptidergic neurons and neuroendocrine cells, which exhibit neuroendocrine differentiation and neuroendocrine marker expression. NENs can occur in any part of the bod…

ObjectivesThis study investigated the protective effects and mechanisms of rhaponticin (Rha) against acinar cell injury in acute pancreatitis (AP).MethodsPancreatic acinar cell injury was induced using multiple in vitro and in vivo AP model…

BACKGROUND: Environmental exposure to trace and heavy metals may influence female fertility, yet their impact on assisted reproductive outcomes remains poorly defined. Maternal diet can potentially modulate metal-related toxicity by influen…

OBJECTIVE: The aim of this study was to investigate the effects of SEPT9 on proliferation, migration, and apoptosis in endometriotic stromal cells and to explore the underlying mechanisms. METHODS: Immunohistochemistry and western blotting…

Endometriosis (EMs) is a disease characterized by the presence of endometrial tissue outside the uterus, which often causes pain, abnormal bleeding, and infertility. Sirtuin 1 (SIRT1)-mediated deacetylation is implicated in the progression …

Ascites, a hallmark of advanced ovarian cancer, severely impairs patient quality of life and contributes to therapeutic resistance. Current management strategies remain primarily palliative, highlighting the urgent need to elucidate the und…

The human ovarian reserve is established prenatally, when granulosa cells encapsulate germ cells to form a pool of quiescent primordial follicles, that ultimately determines the female reproductive and endocrine lifespan. From birth to meno…

Cell invasion through basement membrane (BM) is energetically intensive. How cells produce high ATP levels to power invasion is understudied. By endogenously tagging 20 mitochondrial proteins, we identified a specialized mitochondrial subpo…