Luigi Nappi

Endometriosis is a chronic estrogen-dependent disorder affecting approximately 10% of women of reproductive age. Increasing epidemiological and molecular evidence indicates that it may represent a precursor condition for a subset of ovarian…

PURPOSE: To synthesize current evidence on metabolomic alterations in women with adenomyosis and identify recurrent metabolic patterns that may clarify disease pathophysiology and support biomarker research. METHODS: PubMed/MEDLINE, Scopus…

High-grade carcinomas affecting the ovary or peritoneum may originate from the epithelium of the fallopian tubes. Whilst gynecological cancers are more frequent in post-menopausal patients, 12.1% of ovarian malignancies are diagnosed in pat…

In recent decades, gynecology has undergone a profound transformation driven by technological, pharmacological, and biotechnological innovations that have fundamentally changed the diagnosis, management, and treatment of numerous gynecologi…

BACKGROUND: Subtle uterine lesions are abnormal intracavitary conditions that, while not causing significant anatomical changes, can adversely impact fertility. Identifying these "subtle" lesions is challenging due to arbitrary interpretati…

Background and Objectives: Uterine ectopic pregnancy includes uterine extraendometrial forms such as cervical, intramural, and interstitial pregnancies, whose incidence is increasing with prior uterine surgery and assisted reproduction. Unl…

Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are among the rarest types of uterine tumors. Diagnosis of a UTROSCT is often challenging. Imaging techniques such as ultrasound and MRI are limited in distinguishing UTROSCTs as …

OBJECTIVE: The aim of this narrative review is to evaluate existing questionnaires on predictive models for endometriosis. These symptom-based models have the potential to serve as screening tools for adult women to detect endometriosis. D…

STUDY OBJECTIVE: To evaluate the effectiveness of the Dual Wavelength Laser System (DWLS) diode laser on the treatment of ovarian endometrioma (OMA), with ablation and vaporization of the cystic capsule without performing the stripping tech…

Background and Objectives: Adenomyosis (the presence of ectopic endometrial glands and stroma below the endometrial-myometrial junction) is a benign condition which is increasingly diagnosed in younger women suffering from infertility. The …

The female genital tract can be involved as a secondary manifestation of disseminated lymphomas or leukaemia but can rarely be the primary site of so-called extranodal lymphomas. Primary lymphomas of the female genital tract can affect the …

Background and Objectives: We aimed to evaluate Progression Free Survival (PFS), Overall Survival (OS), and relapse rate in women affected by endometrioid ovarian cancer and synchronous endometrial-ovarian endometrioid cancer (SEO-EC). As s…

INTRODUCTION: Endometriosis is a gynecologic disease affecting approximately 10% of reproductive age women, around 21-47% of women presenting subfertility and 71-87% of women with chronic pelvic pain. Main symptoms are chronic pelvic pain, …

PURPOSE: To evaluate whether laparoscopic treatment with a diode laser is feasible, safe, and effective in symptomatic patients affected by deep endometriosis (DE). METHODS: This retrospective study was performed using medical record data.…

INTRODUCTION: There is an urgent necessity to explore the complex pathophysiological nature of endometriosis, which may enable the rationale for new diagnostic and therapeutic strategies to be discovered. This systematic review aimed to cla…

Background To assess postoperative recurrence rates and likelihood of natural conception in women with deep endometriosis who underwent laparoscopic treatment with diode laser. Methods This is a retrospective study with prospective recordin…

Endometriosis can take one of three forms depending on its clinical presentation and management: endometriotic ovarian cyst (ovarian endometrioma), superficial or peritoneal endometriosis and deep infiltrating endometriosis (DIE).1Among the…

Adenomyosis is defined as the heterotopic presence of endometrial mucosa (glands and stroma) abnormally implanted within myometrium with a range of clinical presentations, the most common being heavy menstrual bleeding and dysmenorrhoea; ne…

Background \nSurgical management of ovarian endometriosis is still debated and controversial. The removal of the cystic capsule with the stripping technique (cystectomy) seems to be most recommended for the lowest recurrence rate, but has \…

This review aimed to critically evaluate the review, observational, cohort, and case-control studies performed so far in order to assess the association between endometriosis and genetics. The search strategies used included an online searc…

Ovarian endometriomas are common manifestations of endometriosis. Surgical excision has been shown to potentially decrease ovarian reserves. In this prospective study, we included 81 patients with ovarian endometriosis. 40 were treated with…

OBJECTIVE: The aim of the present study was to perform a comprehensive review of the literature to provide a complete and clear picture of isthmocele-a hypoechoic area within the myometrium at the site of the uterine scar of a previous cesa…

Background \nDeep infiltrating endometriosis is defined by the European Society of Human Reproduction and Embryology (ESHRE) \nas a peritoneal infiltration of more than 5 mm deep by the endometrial tissue. DIE frequently presents with nodul…

STUDY OBJECTIVE: To estimate the incidence of infection after diagnostic and operative hysteroscopic procedures performed in an in-office setting with different distension media (saline solution or CO2). DESIGN: Prospective, multicenter, o…