RESEARCH QUESTION: Do iron metabolism and ferroptosis influence oocyte and embryo quality in patients with endometriosis undergoing IVF/intracytoplasmic sperm injection (ICSI), or in a mouse model? DESIGN: Fifty-seven patients with laparos…
AbstractPurpose: Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian …
AbstractPurpose: Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian …
Supplementary Materials and Methods
Supplementary Materials and Methods
Suppl Fig S1. Venn diagram of DE genes from 3 group comparisons
Suppl Fig S1. Venn diagram of DE genes from 3 group comparisons
Suppl Fig S2. Kras and Pten pathways in relationship to complement gene expression
Suppl Fig S2. Kras and Pten pathways in relationship to complement gene expression
Suppl Fig S3. Antibody-mediated, complement-induced cytotoxicity
Suppl Fig S3. Antibody-mediated, complement-induced cytotoxicity
Suppl Fig S4. Complement and non-target siRNA
Suppl Fig S4. Complement and non-target siRNA
Suppl Table S1. Differentially expressed genes from different group comparisons
Suppl Table S1. Differentially expressed genes from different group comparisons
Suppl Table S2. Top five canonical pathways from different group comparisons, identified via Ingenuity Pathway Analyses
Suppl Table S2. Top five canonical pathways from different group comparisons, identified via Ingenuity Pathway Analyses
Suppl Table S3. Top five networks from different group comparisons, identified via Ingenuity Pathway Analyses
Suppl Table S3. Top five networks from different group comparisons, identified via Ingenuity Pathway Analyses
The immune tumor microenvironment (TME) of epithelial ovarian cancer (EOC) carries both effector and suppressive functions. To define immune correlates of chemotherapy-induced tumor involution, we performed longitudinal evaluation of biomar…
PURPOSE: Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian tumors p…
Activating mutations of Kras oncogene and deletions of Pten tumor suppressor gene play important roles in cancers of the female genital tract. We developed here new preclinical models for gynecologic cancers, using conditional (Cre-loxP) mi…