Jia-Peng He — Endo Lab

lab-animal 2024

Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse

Cellular and molecular life sciences : CMLS ·doi:10.1007/s00018-024-05143-0

The prostate is a vital accessory gonad in the mammalian male reproductive system. With the ever-increasing proportion of the population over 60 years of age worldwide, the incidence of prostate diseases, such as benign prostatic hyperplasi…

lab-animal 2023

METTL3 is essential for normal progesterone signaling during embryo implantation via m6A-mediated translation control of progesterone receptor

Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2214684120

Embryo implantation, a crucial step in human reproduction, is tightly controlled by estrogen and progesterone (P4) via estrogen receptor alpha and progesterone receptor (PGR), respectively. Here, we report that N6-methyladenosine (m6A), the…

lab-animal 2021

Notch1 is crucial for decidualization and maintaining the first pregnancy in the mouse†

Biology of reproduction ·doi:10.1093/biolre/ioaa222

The endometrium undergoes a pregnancy-delivery-repair cycle multiple times during the reproductive lifespan in females. Decidualization is one of the critical events for the success of this essential process. We have previously reported tha…