Anna Starzinski‐Powitz

ORCID: 0000-0003-4552-4193 · 59 papers in corpus
lab-animal 2012
Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.10.051

OBJECTIVE: To study the function of syndecan-1 (SDC1) and its potential regulator miR-10b in endometriosis. DESIGN: Experimental laboratory study. SETTING: University medical center. PATIENT(S): Not applicable. INTERVENTION(S): The huma…

review 2011
Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis
·doi:10.1002/9781444398519.ch11

The pathogenesis and etiology of endometriosis are difficult to dissect experimentally and remain a challenging problem both clinically and scientifically. The basis of improved understanding is better knowledge of its cell biology. Therefo…

2011
Faculty Opinions recommendation of Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis.
·doi:10.3410/f.10130956.10903054
lab-animal 2010
A conditionally replicative adenovirus, CRAd-S-pK7, can target endometriosis with a cell-killing effect
Human Reproduction ·doi:10.1093/humrep/deq137

BACKGROUND: Novel therapeutic approaches for endometriosis based on molecular strategies may prove to be useful. Conditionally replicative adenoviruses (CRAds) are designed to exploit key differences between target and normal cells. The wil…

lab-animal 2010
Constitutive and tumor necrosis factor-alpha-stimulated activation of nuclear factor-kappaB in immortalized endometriotic cells and their suppression by trichostatin A
Gynecologic and obstetric investigation ·doi:10.1159/000279324

OBJECTIVE(S): To determine whether nuclear factor-kappaB (NF-kappaB) is constitutively and tumor necrosis factor (TNF)-dependently activated in endometriotic cells, whether trichostatin A (TSA) can suppress NF-kappaB activation and suppress…

2010
Faculty Opinions recommendation of Endometriotic stromal cells lose the ability to regulate cell-survival signaling in endometrial epithelial cells in vitro.
·doi:10.3410/f.3124959.2808057
2010
Faculty Opinions recommendation of Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis.
·doi:10.3410/f.1582957.1073055
2010
Faculty Opinions recommendation of Stem cell-like properties of the endometrial side population: implication in endometrial regeneration.
·doi:10.3410/f.6947956.7140054
lab-animal 2010
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2010.11.022

Prostaglandin E2 (PGE2) plays an important role in the pathogenesis of endometriosis. We recently reported that inhibition of COX-2 decreased migration as well as invasion of human endometriotic epithelial and stromal cells. Results of the …

2009
Faculty Opinions recommendation of MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis.
·doi:10.3410/f.1166034.630201
lab-animal 2009
Prostaglandin E2 Regulates Survival of Human Endometriotic Epithelial and Stromal Cells by Integrating EGFR, NFkB, and Wnt Signaling Pathways Through EP2 and EP4 Receptors.
·doi:10.1093/biolreprod/81.s1.150

Endometriosis is a debilitating disease affects up to 20% of reproductive age women characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that results in chronic pelvic pain and i…

lab-animal 2009
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms
Molecular Endocrinology ·doi:10.1210/me.2009-0017

Endometriosis is a benign chronic gynecological disease of reproductive-age women characterized by the presence of functional endometrial tissues outside the uterine cavity. It is an estrogen-dependent disease. Current treatment modalities …

lab-animal 2009
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB and β-CATENIN Pathways and Activation of Intrinsic Apoptotic Mechanisms
·doi:10.1210/jcem.94.7.9993

Endometriosis is a benign chronic gynecological disease of reproductive age women characterized by the presence of functional endometrial tissues outside the uterine cavity. It is an estrogen-dependent disease. Current treatment modalities …

2009
Selective inhibition of prostaglandin E2 signaling inhibits migration and invasion of human endometriotic epithelial and stromal cells through multiple mechanisms
·doi:10.1016/j.fertnstert.2009.07.043
lab-animal 2008
Capsaicin inhibits proliferation of endometriotic cells in vitro
Gynecologic and obstetric investigation ·doi:10.1159/000124275

Treatment of immortalized stromal-like and epithelial-like endometriotic cells with capsaicin resulted in inhibition of proliferation in a concentration-dependent manner. In addition, endometriotic cells are more sensitive to capsaicin trea…

lab-animal 2008
Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans
Fertility and sterility ·doi:10.1016/j.fertnstert.2008.06.050

OBJECTIVE: To determine whether a mixed population of immortalized human endometriosis epithelial and stromal cells is able to induce peritoneal endometriosis in nude mice. DESIGN: Prospective experimental study. Human immortalized endomet…

lab-animal 2008
Interruption of Inflammatory Pathways with JNK Inhibitors Induces Regression of Human Endometriotic Lesions and Restores Progesterone Receptor Sensitivity in Endometrium and Lesions.
·doi:10.1093/biolreprod/78.s1.113b

Endometriosis is one of the most common causes of chronic pelvic pain, which affects over 70 million adult and adolescent women worldwide. The pathophysiology of endometriosis involves endocrine, inflammatory and angiogenic components and t…

lab-animal 2008
TNF-Binding Protein Complex Inhibits TNF-α-Mediated Effects in Human Endometriotic Cell Line.
·doi:10.1093/biolreprod/78.s1.67b

Endometriosis is characterized by the presence of elevated proinflammatory cytokines like TNFα in the peritoneal cavity. Inhibition of TNFα by TNF binding protein-1 (TBP-1), the soluble form of TNFα receptor-1, was effective in animal model…

other 2007
Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms
Endocrinology ·doi:10.1210/en.2007-1168

Endometriosis is a debilitating disease characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that affects up to 20% of women of child-bearing age. Cyclooxygenase-2 (COX-2), a rat…

lab-animal 2007
Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.07.1358

OBJECTIVE: To determine whether immortalized endometriotic cells can be used as potential models to unravel pathophysiology/pathogenesis of endometriosis in humans. DESIGN: In vitro study. Human immortalized endometriotic epithelial and st…

lab-animal 2007
GENE EXPRESSION PROFILES IN HUMAN IMMORTALIZED ENDOMETRIOTIC EPITHELIAL AND STROMAL CELLS: CYCLOOXYGENASE-2 REGULATES CELL PROLIFERATION, MIGRATION AND INVASION
·doi:10.1093/biolreprod/77.s1.158

Endometriosis is a debilitating disease affects up to 20% of reproductive age women characterized by the presence of functional endometrial glandular epithelium and stroma out side the uterine cavity. The pathophysiology of endometriosis re…

lab-animal 2007
Prolonged stimulation with tumor necrosis factor-alpha induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.06.008

The promoter of P receptor isoform B (PR-B) has recently been shown to be hypermethylated in endometriotic tissues, but one question remains as what causes the aberrant methylation. We show that sustained stimulation of an epithelial-like e…

lab-animal 2007
PROSTAGLANDIN E2 SIGNALING IN PATHOPHYSIOLOGY OF ENDOMETRIOSIS IN HUMAN
·doi:10.1093/biolreprod/77.s1.157b

Endometriosis is a debilitating disease affects up to 20% of reproductive age women characterized by the presence of functional endometrial glandular epithelium and stroma out side the uterine cavity. The pathophysiology of endometriosis re…

lab-animal 2007
Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719107302913

The objective of this study is to determine whether trichostatin A (TSA) can suppress the invasiveness of 2 endometriotic cell lines known to be invasive and E-cadherin negative. The membrane invasion culture system was used to assess cell …

other 2005
Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts
Fertility and sterility ·doi:10.1016/j.fertnstert.2004.11.038

OBJECTIVE: To investigate the expression of oxytocin receptor (OTR) in peritoneal and ovarian endometriotic lesions. DESIGN: Retrospective nonrandomized study. SETTING: University hospital endometriosis research center. PATIENT(S): Preme…