Eing‐Mei Tsai

It is believed that endometrial miRNAs contribute to the aetiology of endometriosis in stem cells; however, the mechanisms remain unclear. Here we collected serum samples from patients with or without endometriosis and characterized the miR…

Immune dysregulation may be involved in the development of endometriosis. The anti-inflammatory cytokine IL-10 plays an important role in eliminating unwanted cells and cellular debris in a silent way. We investigated the modulatory role of…

Endometriosis is a common gynecological disease. It is unique to have benign histology but with malignant characteristics. Easy recurrence, multiple organ involvement and malignant transformation potential make endometriosis a complex disea…

Background and Aims: Evidence has shown that polymorphisms of various genes known to be involved in estrogen biosynthesis and function including CYP17, CYP1A1, estrogen receptor-alpha and -beta, are associated with estrogen dependent diseas…

OBJECTIVE: To elucidate the role of interleukin-1β (IL-1β) on cyclooxygenase-2 (COX-2) expression and invasion of endometrioma-derived ectopic endometrial mesenchymal stem cells (EN-MSCs) and to develop an organoid method to study the invas…

BACKGROUND: Phthalates are known to have estrogenic effects in cell models and experimental animals. However, the evidence regarding the effects of phthalates on human reproduction is still limited. We conducted a case-control study to dete…

OBJECTIVE: To elucidate the role of endometrial stem-progenitor cells in the etiology of endometriosis and to develop an animal model to study the invasion ability of endometrial cells. DESIGN: Gene expression and cell function studies wer…

OBJECTIVE: Abdominal wall endometriosis is rare, with an incidence of 0.03-0.47% following cesarean delivery. STUDY DESIGN: The study reviewed abdominal wall endometriomas during an 8-year period in the Department of Obstetrics and Gynecol…

OBJECTIVE: To investigate the involvement of inflammation in the development of endometriosis. DESIGN: Case-control study to investigate the association between endometriosis and four inflammation-related genes: interleukin (IL)-6, IL-10, …

STUDY OBJECTIVE: To describe the modified surgical technique of laparoscopic presacral neurectomy. DESIGN: A prospective trial (Canadian Task Force classification II-1). SETTING: University hospital. PATIENTS: Forty-two women with severe…

BACKGROUND: The aim of the study was to test whether the COMT, CYP1A1 and CYP17 genes influence the risk of developing adenomyosis and endometriosis. METHODS: We conducted two case-control studies, where the cases (n = 198) had either of t…