Pascal Philibert

ORCID: 0000-0001-6384-521X · 4 papers in corpus
lab-animal 2024
Adenomyotic Lesions Are Induced in the Mouse Uterus after Exposure to NSAID and EE2 Mixtures at Environmental Doses
International journal of molecular sciences ·doi:10.3390/ijms25042003

The aim of this study was to assess the long-term effect of exposure to environmentally relevant doses of non-steroidal anti-inflammatory drugs (NSAIDs; ibuprofen, and diclofenac) and 17β-ethinylestradiol (EE2) on the mouse uterus. NSAID-EE…

lab-animal 2023
Cocktails of NSAIDs and 17α Ethinylestradiol at Environmentally Relevant Doses in Drinking Water Alter Puberty Onset in Mice Intergenerationally
International journal of molecular sciences ·doi:10.3390/ijms24065890

Non-steroidal anti-inflammatory drugs (NSAIDs) and 17α-ethinyl-estradiol (EE2) are among the most relevant endocrine-disrupting pharmaceuticals found in the environment, particularly in surface and drinking water due to their incomplete rem…

review 2022
Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health
Frontiers in toxicology ·doi:10.3389/ftox.2022.835360

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin (acetylsalicylic acid), diclofenac and ibuprofen (IBU), and analgesic drugs, such as acetaminophen (APAP, or paracetamol), are widely used to treat inflammation and pain. APAP a…

lab-animal 2021
In the mouse, prostaglandin D2 signalling protects the endometrium against adenomyosis
Molecular human reproduction ·doi:10.1093/molehr/gaab029

Adenomyosis is characterised by epithelial gland and mesenchymal stroma invasion of the uterine myometrium. Adenomyosis is an oestrogen-dependent gynaecological disease in which a number of factors, such as inflammatory molecules, prostagla…