Fei Li

BACKGROUND: Smoking and alcohol consumption have been consistently associated with adverse female reproductive outcomes; however, whether these associations reflect causal effects or are mediated by specific circulating metabolites remains …

INTRODUCTION: Female diseases pose significant challenges in South Asia and Sub-Saharan Africa, particularly among adolescent girls and young women, who often receive insufficient attention. OBJECTIVES: To report patterns and trends of fem…

Extracellular vesicles (EVs) in the mammalian oviduct constitute a key maternal regulatory system that maintains redox balance during early embryogenesis, yet their molecular cargo and functional relevance in human embryos remain poorly def…

Endometriosis (EMS) is a refractory gynecological disease with a high recurrence rate. Its clinical symptoms are mainly dysmenorrhea and infertility, showing diverse manifestations. Due to the atypical clinical symptoms and low specificity …

OBJECTIVE: To evaluate the pregnancy and perinatal outcomes of different phenotypes of polycystic ovary syndrome (PCOS) patients during the frozen embryo transfer (FET) cycles. Additionally, to analyze the T cell balance in the endometrium …

BACKGROUND: Programmed protocols are most commonly chosen as endometrial preparation for women with polycystic ovarian syndrome (PCOS) undergoing frozen-thawed embryo transfer (FET) cycles. However, the efficacy of gonadotropin-releasing ho…

BACKGROUND: Late follicular phase progesterone elevation (LFPE) during ovarian stimulation is associated with reduced live birth rates (LBRs) after cleavage-stage embryo transfer. However, due to better synchronization with a stimulated end…

OBJECTIVES: To explore the incidence of retained embryos (REs) in embryo transfer (ET) cycles and its effects on pregnancy outcomes in women undergoing in vitro fertilization (IVF). METHODS: This was a matched retrospective cohort study in…

STUDY QUESTION: Do extracellular vesicles (EVs) from human Fallopian tubes exert an influence on early embryo development in vitro? SUMMARY ANSWER: Human Fallopian tube EVs carrying miRNAs increase murine embryo viability in vitro. WHAT I…

OBJECTIVE: To investigate the association between different ovarian reserves and reproductive and adverse perinatal outcomes in patients with endometriosis. DESIGN: Retrospective study. SETTING: Reproductive Medicine Center in a hospital.…

OBJECTIVE: To investigate the influence of oviductal extracellular vesicles from patients with endometriosis on early embryo development. DESIGN: In vitro experimental study. SETTING: University-affiliated hospital. PATIENTS: Women with …

OBJECTIVE: To assess whether low-grade inflammation, measured by serum high-sensitivity C-reactive protein (hsCRP) levels, is associated with in vitro fertilization (IVF) outcomes. DESIGN: A retrospective study. SETTING: University-affili…

OBJECTIVE: To determine the optimal endometrial preparation protocol for a frozen embryo transfer in patients with endometriosis. DESIGN: Retrospective cohort study. SETTING: Tertiary care academic medical center. PATIENT(S): One thousan…

The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age, as well as cervical, fec…

BACKGROUND: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas that is associated with substantial morbidity and mortality. Chaiqin chengqi decoction (CQCQD) has been proven clinically to be an effective treatment for AP fo…

OBJECTIVE: To evaluate the effectiveness of ultra-long protocol on reproductive and controlled ovarian hyperstimulation outcome in in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) in infertile women with…

BACKGROUND: Recent studies have consistently shown that AFC and serum AMH are good predictors of ovarian response and have shown strong correlations. However, it is not unusual for reproductive medicine specialists to encounter discordance …

OBJECTIVE: To investigate the association between baseline serum Anti-Müllerian hormone (AMH) levels and IVF/ICSI outcomes in women with polycystic ovary syndrome (PCOS). DESIGN: Retrospective study. SETTING: Reproductive medicine center …

Colorectal cancer ranks third in terms of incidence and second in terms of mortality worldwide. The homeobox transcript antisense intergenic RNA (HOTAIR), which was found to be located on the antisense chain of the homeobox C (HOXC) gene cl…

We explored the independent risk factors associated with cases of spontaneous abortion in infertile patients treated with human-assisted reproductive technology (ART) and established a smooth curve fit and perform a threshold effect analysi…

Disrupted follicular development may result in increased follicular atresia, which is a crucial mechanism of various ovarian pathologies. It has been demonstrated that oxidative stress is associated with disrupted follicular development. Ca…

Abstract Background This retrospective study aimed (1) to evaluate the value of enhanced T2 star-weighted angiography (ESWAN) in diagnosis Adenomyosis(AM). And (2) to estimate the differences of focal AM patients lesion and the peripheral t…

Endometriosis is ectopic growth of endometrial tissue traditionally thought to arise through retrograde menstruation. We aimed to determine if cells derived from endometriosis could enter vascular circulation and lead to hematogenous dissem…

BACKGROUND: The human uterus is traditionally believed to be sterile, while the vaginal microbiota plays an important role in fending off pathogens. Emerging evidence demonstrates the presence of bacteria beyond the vagina. However, a micro…

Endometriosis is an inflammatory gynecological disorder among reproductive-aged women caused by the engraftment and proliferation of endometrial cells outside the uterus, most commonly in the pelvis. It is thought that the disease arises pr…