Cheng Liu

The paradigm shift of lactate from a mere metabolic byproduct to a pleiotropic signaling molecule, coupled with the discovery of lactylation, provides a crucial framework for understanding how metabolic reprogramming drives systemic patholo…

BACKGROUND: Unexplained recurrent spontaneous abortion (URSA) poses a significant clinical challenge with an elusive pathogenesis. FABP4 is crucial for lipid homeostasis and placental development, but its specific role and regulatory mechan…

Traditional view holds that the uterus is a sterile environment. However, with the increased development of molecular biology technologies, this classical theory has been re-examined. Increasing evidence shows that a low-biomass, uniquely s…

OBJECTIVE: To analyse global prevalence data for infertility due to endometriosis from 1990 to 2021, emphasising health inequalities. DESIGN: Population-based study. SETTING: Data from the Global Burden of Disease (GBD) database. POPULAT…

The pathogenesis of stress urinary incontinence (SUI), a condition common in women, remains to be fully elucidated. This study revealed that the incidence of SUI is associated with mitochondrial homeostasis dysregulation following oxidative…

The anatomical positions of pelvic floor organs are maintained mainly by ligaments and muscles. Long-term excessive mechanical tension stimulation of pelvic floor tissue beyond the endurance of ligaments or muscles will lead to the occurren…

The aim of the present study was to investigate the protective effect of integrin β1 in the treatment of stress urinary incontinence (SUI) by electrical stimulation, and the underlying mechanisms by which electrical stimulation regulates th…

Pelvic organ prolapse (POP) is a common and distressing health problem in adult women, but the pathophysiological mechanism is yet to be fully elucidated. Previous studies have indicated that oxidative stress may be associated with POP. Thu…

The present study aimed to reveal the metabolic alterations of the extracellular matrix (ECM) in uterosacral ligament (USL) with pelvic organ prolapse (POP) and to explore the role of transforming growth factor‑β1 (TGF‑β1) in pathogenesis o…

Gestation and delivery can increase intra-abdominal pressure, which are well-known risk factors for Pelvic Organ Prolapse (POP). But the pathogenesis mechanism of POP remains unclear. Our previous research showed that the expression of glut…

Pelvic organ prolapse (POP) is a global health problem, for which the pathophysiological mechanism remains to be fully elucidated. The loss of extracellular matrix protein has been considered to be the most important molecular basis facilit…