Hua Xie

ORCID: 0000-0002-0207-4500 · 2 papers in corpus

lab-animal 2017

Reactive oxygen species downregulate ARID1A expression via its promoter methylation during the pathogenesis of endometriosis

European review for medical and pharmacological sciences

OBJECTIVE: Oxidative stress caused by reactive oxygen species (ROS) plays an important role in the pathogenesis of endometriosis. The gene AT-rich interactive domain 1A (ARID1A), is frequently down regulated and inactivated in endometriosis…

lab-animal 2014

Discovery of a New Series of Naphthamides as Potent VEGFR-2 Kinase Inhibitors

ACS medicinal chemistry letters ·doi:10.1021/ml5000417

Inhibition of VEGFR-2 signaling pathway has already become one of the most promising approaches for the treatment of cancer. In this study, we describe the design, synthesis, and biological evaluation of a new series of naphthamides as pote…