Xinyu Guo

ORCID: 0000-0002-1976-2908 · 5 papers in corpus
other 2025
Ferroptosis and Sterol Biosynthesis Dysregulation in Granulosa Cells of Patients with Diminished Ovarian Reserve
Antioxidants (Basel, Switzerland) ·doi:10.3390/antiox14060749

Granulosa cell (GC) dysfunction contributes to diminished ovarian reserve (DOR). We collected GC and follicular fluid samples from the patients of normal ovarian reserve (NOR) and DOR. RNA-seq of GCs showed that cholesterol/sterol metabolis…

2025
Novel discovery of geraniol and salvianolic acid B in regulating endometriosis recurrence targets LGALS3/VEGFA via integrating AI and biosensors
·doi:10.1016/j.cej.2025.171649
lab-animal 2025
Therapeutic mechanisms of Zi Chong granules against hydroxyurea-induced diminished ovarian reserve based on integrated multi-omics analyses
Journal of ovarian research ·doi:10.1186/s13048-025-01846-5

BACKGROUND: Hydroxyurea (HU) is an antitumor drug. However, HU exposure is associated with diminished ovarian reserve (DOR). Zi Chong granules, a Chinese Medicine, can protect against DOR, but little is known regarding its underlying mechan…

observational 2024
Effect of repeated vitrification of human embryos on pregnancy and neonatal outcomes
Journal of ovarian research ·doi:10.1186/s13048-024-01370-y

BACKGROUND: Repeated cryopreservation of embryos should occasionally be considered when embryos were not suitable for transfer. The effect of re-cryopreservation on embryos remains contentious. METHODS: This retrospective cohort study aime…

observational 2023
Oxidative stress and inflammatory markers in ovarian follicular fluid of women with diminished ovarian reserve during in vitro fertilization
Journal of ovarian research ·doi:10.1186/s13048-023-01293-0

BACKGROUND: Follicular microenvironment has been proposed as an important factor for oocyte grown and maturation. We sought to evaluate the oxidative stress and inflammatory levels in follicular fluid (FF) and association with embryo qualit…