Xiao-Lan Yu

No ORCID on file · 2 papers in corpus

lab-animal 2018

Farnesoid X Receptor Agonist GW4064 Inhibits Aromatase and ERβ Expression in Human Endometriotic Stromal Cells

Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719118808912

Endometriosis is an estrogen-dependent disease. Farnesoid X receptor (FXR) activation has been shown to inhibit estrogen signaling in breast cancer and testicular tumors. However, the role of FXR in endometriosis is still poorly understood.…

lab-animal 2016

IGF-I stimulates ERβ and aromatase expression via IGF1R/PI3K/AKT-mediated transcriptional activation in endometriosis

Journal of molecular medicine (Berlin, Germany) ·doi:10.1007/s00109-016-1396-1

UNLABELLED: Estrogen receptor beta (ERβ, encoded by ESR2 gene) and cytochrome P450 aromatase (encoded by CYP19A1 gene) play critical roles in endometriosis, and the levels of insulin-like growth factor-I (IGF-I) in the peritoneal fluid are …