Paolo Garagnani — Endo Lab

lab-animal 2018

Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain

·doi:10.1101/251397

Capsule Comparative analysis of gene expression signatures from endometriosis and mouse models shows that CACNAα2δs calcium-channel components involved in nociception are targets for the treatment of endometriosis-associated pain. Context D…

lab-animal 2018

Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain

Journal of pain research ·doi:10.2147/jpr.s163611

BACKGROUND: It has been repetitively shown that the transcription factors DLX5 and DLX6 are drastically downregulated in endometriotic lesions when compared with eutopic endometrium. These findings suggest that regulatory cascades involving…

lab-animal 2016

Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis

Human molecular genetics ·doi:10.1093/hmg/ddv452

Dlx5 and Dlx6 are two closely associated homeobox genes which code for transcription factors involved in the control of steroidogenesis and reproduction. Inactivation of Dlx5/6 in the mouse results in a Leydig cell defect in the male and in…