Yoshimasa Hamada

ORCID: 0000-0002-7143-5365 · 2 papers in corpus

lab-animal 2000

Growth-stimulating effect of dienogest, a synthetic steroid, on rodent, canine, and primate mammary glands

Toxicology ·doi:10.1016/s0300-483x(00)00318-8

We observed hyperplasia of the mammary gland in female beagle dogs, but not in female rats and monkeys, in 91-day toxicity studies on dienogest. In order to elucidate a possible mechanism for its development and to account for this species …

lab-animal 1998

Effects of dienogest (a synthetic steroid) on coagulation, fibrinolysis, and platelet aggregation in female monkeys

Toxicology letters ·doi:10.1016/s0378-4274(98)00109-x

We investigated the effects of dienogest (0.1-10 mg/kg per day, p.o.) on coagulation, fibrinolysis and platelet aggregation in female rhesus monkeys. Then, we also examined those of medroxyprogesterone acetate (MPA, 10 mg/kg per day, p.o.) …