Xinmei Zhang

Endometriosis, a prevalent gynecological disease affecting women's health, involves altered immune function. This study investigates the immune checkpoint protein, V-domain immunoglobulin suppressor of T cell activation (VISTA) as a therape…

OBJECTIVE: To describe a mesentery-preserving, nerve-sparing laparoscopic technique for rectal endometriosis. DESIGN: Retrospective cohort study. SETTING: Single centre. POPULATION OR SAMPLE: Women requiring bowel resection for rectal en…

BACKGROUND: Extrinsic adenomyosis exhibits heterogeneous clinical symptoms, with pain being more commonly reported. The relationship between magnetic resonance imaging (MRI) feature and symptom remains unclear. OBJECTIVE: To evaluate the pe…

MOTIVATION: Normalization is a critical step in quantitative PCR (qPCR) and droplet digital PCR (ddPCR) experiments to ensure accurate and reproducible gene expression analysis. However, commonly used endogenous controls such as miR-16 for …

The studies on how mast cells mediate endometriosis pain are still limited. Mas-related G protein-coupled receptor member X2 (MRGPRX2), a receptor expressed on mast cells, participates in pain, inflammation, and itch. However, it is still u…

Abstract Endometriosis is a common yet often underdiagnosed condition, partly due to the lack of reliable diagnostics. This study examines the clinical feasibility of a blood-based, miRNA-driven test to diagnose endometriosis and address th…

Endometriosis is a common yet often underdiagnosed condition, partly due to the lack of reliable diagnostics. This study examines the clinical feasibility of a blood-based, miRNA-driven test to diagnose endometriosis and address the challen…

Endometriosis is a prevalent gynaecological disorder characterized by estrogen-dependent lesions. Pain-particularly dysmenorrhea, chronic pelvic pain, and dyspareunia-is the hallmark symptom of endometriosis. While pain mechanisms remain po…

INTRODUCTION: The clinical presentation of endometriosis varies widely, from asymptomatic to severe with often infertility also presented. Screening methods today include imaging, which is subject to operator expertise and poor specificity.…

Endometriosis is an estrogen-dependent inflammatory gynecological disease whose pathogenesis is unclear. C-C motif chemokine ligand 18 (CCL18), a chemokine, is involved in several inflammatory diseases. In this study, we aimed to investigat…

Aberrantly expressed circRNAs affects various anti-tumour immune responses and immune cell regulation. However, the exact function of circGLIS2 on the pathogenesis of EMs remains unclear. In this study, we found that circGLIS2 was upregulat…

Background: The adverse perinatal outcome caused by adenomyosis has been widely concerned recently, but little attention has been paid to whether the positional relationship between placenta and adenomyotic lesion influences the maternal an…

Abstract Purpose Although adenomyosis is a common and benign gynecological disease, the specific pathogenesis of this condition has yet to be fully elucidated. It is difficult to culture primary cells of the ectopic endometrial epithelia an…

Importance: Adenomyosis is a common chronic gynecological disorder, and its treatment is an unmet need. New therapies need to be developed. Mifepristone is being tested for adenomyosis treatment. Objective: To determine whether mifepristone…

Pain is one of the main clinical symptoms of endometriosis, but its underlying mechanism is still not clear. Recent studies have shown that the secretory mediators of mast cells activated by estrogen are involved in the pathogenesis of endo…

Lack of sensitive biomarkers in the early stages of endometriosis (EMs) results in delayed diagnosis and intervention. Long non-coding RNAs (lncRNAs) have prognostic and diagnostic values in various diseases. However, the prognostic and dia…

Additional file 1. Clinical characteristics of endometriosis and control patients in this study.

Patients with adenomyosis are hypercoagulable and often accompanied by anemia, but the specific changes in anemia-related coagulation parameters are still unclear. This study investigated the changes in and influencing factors of coagulatio…

Endometriosis remains a common but challenging gynecological disease among reproductive-aged women with an unclear pathogenesis and limited therapeutic options. Numerous pieces of evidence suggest that NF-κB signaling, a major regulator of …

OBJECTIVE: This prospective cohort study aimed to compare the clinical efficacy and safety of goserelin 10.8 mg administered trimonthly with goserelin 3.6 mg administered monthly in premenopausal females with symptomatic adenomyosis. METHOD…