Xiaoyan Liang

Chronic endometritis (CE) is a plasma cell-related endometrial inflammatory phenotype that may compromise fertility, while endometriosis (EM) is an immune-mediated inflammatory disorder. However, whether EM is associated with CD138-defined …

BACKGROUND: Mitochondrial dysfunction contributes to poor embryo quality and recurrent assisted reproductive technology (ART) failure. Mitochondrial transplantation (MIT), which involves supplementing oocytes with exogenous mitochondria, ha…

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with potential reproductive toxicity, yet their profiles in follicular fluid and impacts on human fertility remain unclear. Given the importance of diet as…

BACKGROUND: Laparoscopic ethanol sclerotherapy is a fertility-preserving alternative for ovarian endometriomas, but the appropriate ethanol exposure duration remains uncertain. We compared expectant management with 5- and 15-minute ethanol …

STUDY OBJECTIVE: To compare the safety and efficacy of laparoscopic versus transvaginal ethanol sclerotherapy in patients with ovarian endometriomas (OEMs). DESIGN: Preliminary retrospective cohort study. SETTING: Reproductive Medicine Re…

Adenomyosis is a common gynecological disorder with incompletely understood pathogenesis. Through single-cell RNA sequencing of adenomyosis tissues, we identified epithelial-endothelial transition (EET) as a key pathological mechanism and d…

Endometriosis, a chronic inflammatory condition characterized by pain and infertility, remains a clinical challenge. Current hormonal and surgical treatments are often limited by side effects and high recurrence rates. In search of more eff…

STUDY OBJECTIVE: To evaluate the effects of a 3-stage treatment strategy featured by cold-knife adenomyomectomy, enhanced endometrial protection and postoperative uterine monitoring for severe diffuse adenomyosis on IVF/ICSI and perinatal o…

PURPOSE: To compare the effects of the gonadotrophin-releasing hormone (GnRH) agonist protocol, GnRH antagonist protocol, progestin-primed ovarian stimulation (PPOS) protocol, and mild stimulation/natural cycle protocol on the cumulative li…

Poor ovarian response (POR) is a challenge in reproductive medicine, often leading to suboptimal outcomes in IVF/ICSI cycles. Autologous platelet-rich plasma (PRP) injections have emerged as a potential therapy to enhance ovarian function. …

Patients with systemic lupus erythematosus (SLE) often have decreased fertility. Gene translation is crucial to oocyte meiosis and development. However, it remains unclear how SLE affects this process. Here, we used single-cell transcriptom…

INTRODUCTION: A significant proportion of women in their reproductive years are afflicted by endometriosis. And one of the major contributing factors to infertility linked to ovarian endometriosis is thought to be oocyte quality. The precis…

Abstract Adenomyosis is a prevalent and non-cancerous uterine disease which can significantly impaired the fertility of reproductive-age women. However, the etiology, as well as the cellular and molecular mechanism underlying adenomyosis re…

INTRODUCTION: Adenomyosis is a prevalent gynaecological disorder affecting women of reproductive age, yet the underlying etiology and cellular-molecular mechanisms driving its pathogenesis remain poorly understood. Gonadotropin-releasing ho…

OBJECTIVE: The aim of this study was to investigate the relationship between endometrial thickness (EMT) on human chorionic gonadotropin (hCG) day in the progestin-primed ovarian stimulation (PPOS) protocol and pregnancy outcomes in the sub…

BACKGROUND: With the increasing incidence of obesity and the childbearing-age delay among women, a debate over obesity's impacts on pregnancy and neonatal outcomes becomes hot. The potential negative effects of obesity and aging on fertilit…

PURPOSE: This study aimed to evaluate the effectiveness of a random forest (RF) model in predicting clinical pregnancy outcomes from intrauterine insemination (IUI) and identifying significant factors affecting IUI pregnancy in a large Chin…

Female fecundity declines in a nonlinear manner with age during the reproductive years, even as ovulatory cycles continue, which reduces female fertility, disrupts metabolic homeostasis, and eventually induces various chronic diseases. Desp…

BACKGROUND: Polycystic ovary syndrome (PCOS) is known to be associated with chronic low-grade inflammation and endometrial dysfunction. Chronic endometritis (CE) is a type of local inflammation that can contribute to endometrial dysfunction…

Endometriosis is a refractory and recurrent gynecological condition which affects about 10 % of reproductive-age women. The dysfunctional immune system is a well-established element in disease pathogenesis. Pyroptosis, a novel form of infla…

BACKGROUND: To compare the efficacy and safety of follitropin delta in its individualized fixed-dose regimen with follitropin alfa in a conventional adjustable dosing regimen in Chinese women.  METHODS: This was a subgroup analysis of the r…

Cesarean section scar diverticulum (CSD) has become a formidable obstacle preventing women receiving CS from reproducing. However, the pathogenesis of CSD remains unexplored. In this study, we characterized the cervical microbiota, metabolo…

The aim of this study was to explore whether the presence of intra-cavitary fluid (ICF) influences the pregnancy outcomes of patients with caesarean section (CS) in embryo transfer cycles. A total of 8494 transferred cycles of 4924 women we…

To explore the expression profiles of mRNAs, long-noncoding RNAs (lncRNAs), circular RNAs (circRNAs) and construct the competitive endogenous RNA networks in granulosa cells (GCs) of infertile women with ovarian endometriosis. RNA sequencin…