Stephen Lye

No ORCID on file · 4 papers in corpus
review 2021
Landscape of Preterm Birth Therapeutics and a Path Forward
Journal of clinical medicine ·doi:10.3390/jcm10132912

Preterm birth (PTB) remains the leading cause of infant morbidity and mortality. Despite 50 years of research, therapeutic options are limited and many lack clear efficacy. Tocolytic agents are drugs that briefly delay PTB, typically to all…

observational 2016
Original Article Expression of Extracellular Matrix-Remodeling Proteins Is Altered in Vaginal Tissue of Premenopausal Women With Severe Pelvic

Aim: The molecular etiology of pelvic organ prolapse (POP) is complex and not well understood. We compared the expression/ activity of extracellular matrix (ECM)-processing (procollagen I N-proteinase / a disintegrin and metalloproteinase w…

observational 2014
Expression of extracellular matrix-remodeling proteins is altered in vaginal tissue of premenopausal women with severe pelvic organ prolapse
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719113512529

AIM: The molecular etiology of pelvic organ prolapse (POP) is complex and not well understood. We compared the expression/activity of extracellular matrix (ECM)-processing (procollagen I N-proteinase/ a disintegrin and metalloproteinase wit…

lab-animal 2014
Inhibition of infection-mediated preterm birth by administration of broad spectrum chemokine inhibitor in mice
Journal of cellular and molecular medicine ·doi:10.1111/jcmm.12307

Preterm birth (PTB) is the single most important cause of perinatal and infant mortality worldwide. Maternal infection can result in PTB. We investigated the ability of a Broad Spectrum Chemokine Inhibitor (BSCI) to prevent infection-induce…