Ravikumar Balasubramanian

meta-analysis 2025

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

Nature genetics ·doi:10.1038/s41588-025-02156-8

Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female i…

other 2024

Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum

medRxiv : the preprint server for health sciences ·doi:10.1101/2024.03.19.24304530

Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 6…

review 2011

The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations

Endocrine Reviews ·doi:10.1210/er.2010-0007

A widely dispersed network of hypothalamic GnRH neurons controls the reproductive axis in mammals. Genetic investigation of the human disease model of isolated GnRH deficiency has revealed several key genes crucial for GnRH neuronal ontogen…