Mathieu Leboeuf

No ORCID on file · 9 papers in corpus
lab-animal 2016
Augmented Angiogenic Factors Expression via FP Signaling Pathways in Peritoneal Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2016-1569

CONTEXT: Angiogenesis is required for ectopic endometrial tissue growth. Our previous studies showed that prostaglandin F2α (PGF2α) biosynthetic enzymes and receptor were markedly elevated in endometriotic lesions and that PGF2α is a potent…

observational 2016
Promotion of angiogenesis and proliferation cytokines patterns in peritoneal fluid from women with endometriosis
Journal of Reproductive Immunology ·doi:10.1016/j.jri.2016.01.005

Studies have long sought specific cytokines that could characterize endometriosis. Either due to variations between study designs regarding the assessment criteria for the cytokine or to low power resulting from small sample size, no factor…

other 2014
Low abdominal subcutaneous preadipocyte adipogenesis is associated with visceral obesity, visceral adipocyte hypertrophy, and a dysmetabolic state
Adipocyte ·doi:10.4161/adip.29385

Subcutaneous adipose tissue expansion through adipogenesis is increasingly recognized as a major determinant of body fat distribution and obesity-related cardiometabolic alterations. Our objective was to assess whether adipogenic rates of c…

lab-animal 2014
Macrophage migration inhibitory factor is involved in ectopic endometrial tissue growth and peritoneal-endometrial tissue interaction in vivo: a plausible link to endometriosis development
PloS one ·doi:10.1371/journal.pone.0110434

Pelvic inflammation is a hallmark of endometriosis pathogenesis and a major cause of the disease's symptoms. Abnormal immune and inflammatory changes may not only contribute to endometriosis-major symptoms, but also contribute to ectopic en…

other 2013
Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.08.016

OBJECTIVE: To investigate prostaglandin (PG) biosynthesis and catabolism pathways in eutopic and ectopic endometrium of women with endometriosis. DESIGN: Retrospective study. SETTING: Human reproduction research laboratory. PATIENT(S): F…

lab-animal 2012
Macrophage migration inhibitory factor is involved in a positive feedback loop increasing aromatase expression in endometriosis
The American Journal of Pathology ·doi:10.1016/j.ajpath.2012.05.018

Immune-endocrine interplay may play a major role in the pathogenesis of endometriosis. In the present study, we have investigated the interaction between macrophage migration inhibitory factor (MIF), a major pro-inflammatory and growth-prom…

lab-animal 2012
Soluble human IL-1 receptor type 2 inhibits ectopic endometrial tissue implantation and growth: identification of a novel potential target for endometriosis treatment
The American Journal of Pathology ·doi:10.1016/j.ajpath.2012.06.022

Endometriosis is often associated with a chronic pelvic immuno-inflammatory process, which is closely related to disease pathogenesis and major symptoms. Our studies led to the detection of a marked imbalance between IL-1 and its natural in…

observational 2011
Distinct expression of the soluble and the membrane-bound forms of interleukin-1 receptor accessory protein in the endometrium of women with endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.12.056

OBJECTIVE: To investigate interleukin (IL) 1 receptor accessory protein (IL1RAcP) expression in the eutopic endometrium of women with endometriosis. DESIGN: Retrospective study. SETTING: Human reproduction research laboratory. PATIENT(S)…

observational 2008
Imbalance in the peritoneal levels of interleukin 1 and its decoy inhibitory receptor type II in endometriosis women with infertility and pelvic pain
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.06.019

OBJECTIVE: To evaluate the levels of interleukin-1beta (IL1beta) and its inhibitory soluble interleukin-1 receptor type II (IL1R2) in the peritoneal fluid (PF) of normal women and patients with endometriosis suffering from pelvic pain and i…