We explore the genetic mechanisms underlying fibromyalgia, a chronic heritable syndrome. We conduct genome-wide association studies (GWAS) of fibromyalgia in European, African, and Latin American ancestry subjects, combining data from sever…
BACKGROUND: Illicit drug use may lead to dependence on those drugs, is associated with various psychiatric disorders, and can have hazardous, sometimes life-threatening, consequences. We investigated the genetic architecture underlying the …
Erectile dysfunction is attributable to numerous biological and psychological issues, and its prevalence increases with age. We conducted genome-wide association studies of erectile dysfunction in AllofUs subjects of European and African an…
BACKGROUND: Alcohol consumption is associated with numerous negative social and health outcomes. These associations may be direct consequences of drinking, or they may reflect common genetic factors that influence both alcohol consumption a…
Individuals suffering from chronic pain develop substance use disorders (SUDs) more often than others. Understanding the shared genetic influences underlying the comorbidity between chronic pain and SUDs will lead to a greater understanding…
ABSTRACT Endometriosis is a chronic gynecologic disease that causes pelvic pain and is often seen in association with depression and anxiety. The association with these mental health conditions was previously linked to chronic pain, althoug…
IMPORTANCE: Endometriosis is a common chronic gynecologic pathology with a large negative impact on women's health. Beyond severe physical symptoms, endometriosis is also associated with several psychiatric comorbidities, including depressi…