Kashir J

ORCID: 0000-0002-5056-8222 · 2 papers in corpus

case-report 2026

Pathogenic homozygous PLCZ1 mutation reduces sperm protein levels with a simulated reduction of PIP2 binding: a case report

Reproduction & fertility ·doi:10.1530/raf-25-0085

ABSTRACT: Mammalian oocyte activation is driven by intracellular calcium (Ca2+) oscillations induced by sperm-specific phospholipase C zeta (PLCζ). Sperm PLCζ deficiency is linked to male infertility caused by oocyte activation deficiency. …

review 2022

Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application

Human reproduction open ·doi:10.1093/hropen/hoac003

BACKGROUND: Oocyte activation deficiency (OAD) is attributed to the majority of cases underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte activation encompasses a series of concerted events, trigger…