Heng Cai

ORCID: 0000-0003-4871-1744 · 4 papers in corpus
lab-animal 2026
CX3CR1/P2X4R signaling-mediated spinal microglial M1 polarization contributes to chronic pelvic pain in endometriosis
International Immunopharmacology ·doi:10.1016/j.intimp.2026.116471

BACKGROUND: Deeply infiltrating endometriosis (DIE), characterized by its extrauterine invasion, is strongly associated with chronic pelvic pain (CPP). Peripheral-central sensitization synergistically contribute to the pathogenesis of CPP i…

lab-animal 2024
Hypoxia-induced Semaphorin 3A promotes the development of endometriosis through regulating macrophage polarization
International Immunopharmacology ·doi:10.1016/j.intimp.2024.112559

BACKGROUND: Semaphorin 3A (Sema3A) is a member of neural guidance factor family well-known for inducing the collapse of nerve cell growth cone and regulating nerve redistribution. It also has been characterized as an immunoregulatory and tu…

lab-animal 2023
Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2023.03.032

OBJECTIVE: To explore the role of gut dysbiosis-derived β-glucuronidase (GUSB) in the development of endometriosis (EMs). DESIGN: 16S rRNA sequencing of stool samples from women with (n = 35) or without (n = 30) endometriosis and from a mo…

lab-animal 2018
Long Non-coding RNA LINC00339 Stimulates Glioma Vasculogenic Mimicry Formation by Regulating the miR-539-5p/TWIST1/MMPs Axis
Molecular therapy. Nucleic acids ·doi:10.1016/j.omtn.2017.11.011

Glioma is recognized as a highly angiogenic malignant brain tumor. Vasculogenic mimicry (VM) greatly restricts the therapeutic effect of anti-angiogenic tumor therapy for glioma patients. However, the molecular mechanisms of VM formation in…