Matteo Boretto

ORCID: 0000-0002-5515-204X · 3 papers in corpus
lab-animal 2019
Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids
Scientific reports ·doi:10.1038/s41598-018-38376-8

Successful pregnancy requires the establishment of a complex dialogue between the implanting embryo and the endometrium. Knowledge regarding molecular candidates involved in this early communication process is inadequate due to limited acce…

lab-animal 2019
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening
Nature cell biology ·doi:10.1038/s41556-019-0360-z

Endometrial disorders represent a major gynaecological burden. Current research models fail to recapitulate the nature and heterogeneity of these diseases, thereby hampering scientific and clinical progress. Here we developed long-term expa…

lab-animal 2017
Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability
Development (Cambridge, England) ·doi:10.1242/dev.148478

The endometrium, which is of crucial importance for reproduction, undergoes dynamic cyclic tissue remodeling. Knowledge of its molecular and cellular regulation is poor, primarily owing to a lack of study models. Here, we have established a…