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BACKGROUND: Endometriosis is a debilitating gynaecological disorder with an elusive pathogenesis. While gut microbiota dysbiosis has been implicated, the causal role of gut-peritoneum microbial translocation and the specific mechanisms driv…
AIMS: Aberrantly expressed MPHOSPH9 has been reported to be associated with poor prognosis in many diseases. Previous study indicates that MPHOSPH9 is abnormally expressed in patients with uterine fibroids (UFs). This study focused on the p…
A considerable number of women of reproductive age suffer from endometriosis worldwide. There is a significant physical, mental, and financial burden on patients affected by this condition in terms of pelvic pain, either continuously or int…
Background: Endometriosis, characterized by extrauterine endometrial tissue, leads to irregular bleeding and pelvic pain. Menstrual retrograde theory suggests fragments traverse fallopian tubes, causing inflammation and scar tissue. Prevale…
Additional file 1: Table S1. Selected instrumental variables for coagulation factors in this study. Table S2. Summary statistics of the causal estimates of coagulation factors on endometriosis in UK Biobank. Table S3. The results of leave-o…
Additional file 1: Table S1. Selected instrumental variables for coagulation factors in this study. Table S2. Summary statistics of the causal estimates of coagulation factors on endometriosis in UK Biobank. Table S3. The results of leave-o…
Additional file 2: Fig. S1. Scatter plots for MR analyses of the causal effect of 11 coagulation factors on endometriosis in UK Biobank. Fig. S2. Plots of leave-one-out analyses for the causal associations in UK Biobank. Fig. S3. Scatter pl…
Additional file 2: Fig. S1. Scatter plots for MR analyses of the causal effect of 11 coagulation factors on endometriosis in UK Biobank. Fig. S2. Plots of leave-one-out analyses for the causal associations in UK Biobank. Fig. S3. Scatter pl…
Abstract Background Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6–10% of all reproductive-aged women. Endometriosis is a condition in which endometrial tissue, which …
Abstract Background Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6–10% of all reproductive-aged women. Endometriosis is a condition in which endometrial tissue, which …
BACKGROUND: Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6-10% of all reproductive-aged women. Endometriosis is a condition in which endometrial tissue, which normally…
The processes underlying adenomyosis are similar to those of tumor metastasis, and it is defined as progressive invasion by the endometrium and the subsequent creation of ectopic lesions. GRIM-19 regulates cell death via the mitochondrial r…
Although high-grade serous cancer (HGSC) accounts for >70% of ovarian epithelial cancers, it is rarely associated with endometriosis. No previous study has reported an association between the malignant transformation of uterine ligament end…
The epithelial-to-mesenchymal transition may play a role in adenomyosis. GRIM19 expression is downregulated in adenomyotic lesions, and the effects of this downregulation in adenomyosis remain relatively unclear. In this study, we aimed to …
OBJECTIVE: To study the expression of the gene associated with retinoid-interferon (IFN)-induced mortality 19 (GRIM-19) in the endometrial tissue of patients with adenomyosis and to describe the possible pathogenic mechanisms of this phenom…
Objective To investigate the role of phosphorylated-signal transduction and activator of transcription 3( p-STAT3)( Y705) and vascular endothelial growth factor( VEGF) in the development of adenomyosis by detecting the expression of p-STAT3…