Peter Lembessis — Endo Lab

lab-animal 2004

Glucocorticoid receptor function suppresses insulin-like growth factor 1 activity in human KLE endometrial-like cells

In vivo (Athens, Greece)

We analysed the glucocorticoid receptor (GR) regulation on the expression of insulin-like growth factor 1 (IGF-1), type I IGF receptor (IGF-1.R), IGF-binding protein 3 (IGFBP-3), urokinase-type plasminogen activator (uPA) and uPA receptor (…

case-report 2003

Mutation analysis of BrCA1, BrCA2, and p53 versus soluble HLA class I and class II in a case of familial endometriosis

Fertility and sterility ·doi:10.1016/s0015-0282(02)04665-4

OBJECTIVE: To investigate possible correlation(s) between mutations of BrCA1, BrCA2, and p53 genes versus soluble HLA expression in familial endometriosis. DESIGN: Mutation analysis. SETTING: University teaching departments and hospital. …

other 2003

Urokinase-type plasminogen activator and insulin-like growth factor-binding protein 3 mRNA expression in endometriotic lesions and eutopic endometrium: implications for the pathophysiology of endometriosis

Annals of the New York Academy of Sciences ·doi:10.1196/annals.1290.025

The peritoneal fluid of women with endometriosis contains an increased insulin-like growth factor 1 (IGF-1) bioavailability, which is produced by limited hydrolysis of urokinase-type plasminogen activator (uPA) on IGF-binding protein 3 (IGF…

lab-animal 2001

Increased insulin-like growth factor 1 activity can rescue KLE endometrial-like cells from apoptosis

Molecular medicine (Cambridge, Mass.) ·doi:10.1007/bf03401835

BACKGROUND: The peritoneal fluid (PF) of women with endometriosis contains protease(s) activity able to hydrolyze insulin-like growth factor-binding protein 3 (IGFBP-3), increasing the bioavailability of insulin-like growth factor-1 (IGF-1)…