Xuan Chen

ORCID: 0000-0001-5776-4931 · 3 papers in corpus
lab-animal 2025
Decreased miR-128-3p in serum exosomes from polycystic ovary syndrome induces ferroptosis in granulosa cells via the p38/JNK/SLC7A11 axis through targeting CSF1
Cell death discovery ·doi:10.1038/s41420-025-02331-0

Increasing evidence suggests that non-coding small RNAs (miRNAs) carried by exosomes (EXOs) play important roles in the development and treatment of polycystic ovary syndrome (PCOS). In this study, we demonstrate that PCOS mouse serum-deriv…

lab-animal 2023
High mobility group box 1 promotes endometriosis under hypoxia by regulating inflammation and autophagy in vitro and in vivo
International Immunopharmacology ·doi:10.1016/j.intimp.2023.111397

BACKGROUND: Endometriosis is a chronic disease. Our previous study identified a positive correlation between high mobility group box 1 (HMGB1) and endometriosis, and HMGB1 and inflammation. However, the precise roles of HMGB1 in endometrios…

lab-animal 2021
HMGB1 Mediated Inflammation and Autophagy Contribute to Endometriosis
Frontiers in endocrinology ·doi:10.3389/fendo.2021.616696

AIM: High mobility group box (HMGB)-1 has been implicated in endometriosis due to the important regulatory roles of inflammation in endometriosis. The aim of the present study was to explore the roles of HMGB-1 in endometriosis and to eluci…