Kevin G. Osteen

Endometriosis is a common gynecologic disorder characterized by ectopic attachment and growth of endometrial tissues. Resveratrol is a natural polyphenol with antiproliferative and anti-inflammatory properties. Our objective was to study th…

Previous studies have demonstrated that proliferation of endometrial stroma (ES) in vitro is inhibited by a number of statins in a concentration-dependent manner. An in vitro model of endometriosis found that lovastatin also abolished angio…

CONTEXT: Endometriosis is a common condition associated with infertility and pelvic pain in women. Recent in vitro studies have shown that statins decrease proliferation of endometrial stroma (ES) and inhibit angiogenesis. OBJECTIVE: The a…

Laboratory and population-based studies suggest that exposure to environmental toxicants may be one of several triggers for the development of endometriosis. We discuss evidence that modulation of the endometrial endocrine-immune interface …

Endometriosis is one of the most common causes of chronic pelvic pain, which affects over 70 million adult and adolescent women worldwide. The pathophysiology of endometriosis involves endocrine, inflammatory and angiogenic components and t…

Endometriosis is an estrogen dependent gynecological disease that can result in an array of problems from severe chronic pelvic pain to infertility. It is caused by the ectopic growth of the endometrial tissue at extrauterine sites, predomi…

Problem: The environmental contaminant 2,3,7,8‐tetracholorodibenzo‐p‐dioxin (TCDD) has been suggested to play a role in the etiology of endometriosis, but whether women develop this disease due to a prior exposure to endocrine disruptors is…

Whether environmental toxicants impact an individual woman's risk for developing endometriosis remains uncertain. Although the growth of endometrial glands and stroma at extra-uterine sites is associated with retrograde menstruation, our st…

CONTEXT: Endometriosis, the growth of endometrial tissue outside the uterus, is principally an estrogen-dependent disease. In contrast, exposure to progesterone during pregnancy or therapeutically has been shown to provide benefit to some w…

Two recent studies reported in this issue of Fertility and Sterility have explored important issues regarding the understanding and diagnosing of endometriosis. These studies emphasize the complexity of endometriosis and underscore the diff…

OBJECTIVE: To analyze endometrial progesterone receptor (PR) expression in women with endometriosis compared with disease-free women and to assess the impact of in vitro 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on PR isotype expr…

OBJECTIVE: To discuss the role that reduced endometrial responsiveness to progesterone (P) might play in the pathophysiology of endometriosis. DESIGN: A review of experimental evidence regarding the failure of P to regulate the expression …

BACKGROUND: Endometriosis is a common gynaecological problem of uncertain aetiology. It affects primarily young, reproductive-aged women and can result in chronic pelvic pain and infertility. Current approved therapies have significant side…

The basic biology of the human endometrium is intimately linked to cyclic ovarian steroid production, creating a unique endometrial architecture which supports and controls the highly invasive events of implantation and placentation. During…

OBJECTIVE: To test whether fragments of human endometrium transduced with the green fluorescent protein (GFP) cDNA and transplanted into nude mice can be noninvasively visualized. DESIGN: A murine experimental model for human endometriosis…

Endometriosis is a disease in which the lining of the uterus (endometrium), shed at the time of menstruation, becomes established at sites such as the peritoneum and ovaries. These explants develop a rich blood supply that enables them to s…

Hull, M. Louise; Carnock-Jones, D. Stephen; Chan, Clement L. K.; Bruner-Tran, Kaylon L.; Osteen, Kevin G.; Tom, Brian D. M.; Fan, Tai-Ping D.; Smith, Stephen K.