Christina Pentafragka

No ORCID on file · 2 papers in corpus

lab-animal 2021

In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults

Journal of pharmaceutical sciences ·doi:10.1016/j.xphs.2021.10.010

We evaluated the environment in TIM-1 luminal compartments using paracetamol and danazol solutions and suspensions and the fed state configuration. Data were compared with recently published data in healthy adults. TIM-1 experiments were pe…

rct 2020

Disposition of two highly permeable drugs in the upper gastrointestinal lumen of healthy adults after a standard high-calorie, high-fat meal

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences ·doi:10.1016/j.ejps.2020.105351

OBJECTIVES: To quantify the presence of two model highly permeable drugs, paracetamol and danazol, in the upper gastrointestinal lumen under conditions simulating the situation after disintegration of immediate release dosage forms administ…