Huang L

Excess body fat and its distribution are known to influence female reproductive function; however, the relationship between emerging body fat-related indices and infertility remains insufficiently explored. This study aimed to investigate t…

BACKGROUND: Endometriosis and major depressive disorder (MDD) pose significant global health burdens. Despite pathophysiological overlaps, existing epidemiological studies predominantly examine their unidirectional associations, often const…

BACKGROUND: The selection of a frozen-thawed embryo transfer (FET) strategy requires balancing the potential for improved clinical pregnancy and live birth outcomes against the risk of multiple pregnancy. However, comprehensive evaluations …

BACKGROUND: Sarcopenia is the progressive, widespread loss of skeletal muscle mass, strength, and function, which happens as a result of aging. This study aims to analyze the alterations in serum protein profiles and explore a biomarker of …

OBJECTIVE: To compare dydrogesterone versus levonorgestrel-releasing intrauterine system (LNG-IUS) for abnormal uterine bleeding (AUB) management with long-term follow-up and etiology-stratified analysis. METHODS: This single-center retros…

STUDY QUESTION: What is the optimal timing of progesterone exposure to achieve live births for day-6 blastocysts in artificial frozen-thawed embryo transfer (FET) cycles? SUMMARY ANSWER: Live birth rates (LBRs) were comparable between day-…

BACKGROUND: In this study, we aimed to explore the effect of the timing of surgical management of hydrosalpinx on in vitro fertilization/intracytoplasmic single-sperm injection (IVF/ICSI) pregnancy outcomes in patients with tubal factor inf…

INTRODUCTION: The female reproductive system undergoes hormone-driven cyclical changes during the menstrual cycle and further alterations after menopause. However, the impact of these changes on imaging parameters remains unclear. This stud…

Preeclampsia (PE) is a major cause of maternal and perinatal morbidity. Because abnormal fat distribution is closely related to metabolic dysfunction, vascular injury, and hypertensive disorders during pregnancy, clarifying its genetic rela…

BACKGROUND: Immune tolerance breakdown at the maternal-fetal interface is implicated in unexplained recurrent pregnancy loss (URPL), but the interplay between T cell hyperactivation and dendritic cells (DCs)-mediated signaling remains poorl…

This narrative review synthesizes the latest advances in nano-diagnostic and therapeutic reagents for acute pancreatitis (AP), based on peer-reviewed experimental and preclinical studies published in recent years. AP endangers life through …

Endometriosis is an estrogen-dependent disorder influenced by dysregulated steroidogenesis, oxidative stress, and inflammation. Bisphenol A (BPA), a common endocrine disruptor, has been associated with reproductive dysfunction, but its deve…

BACKGROUND: In clinical practice, repeated oocyte retrieval cycles are often necessary for patients with diminished ovarian reserve (DOR). It has been hypothesized that the mechanical stimulation from the initial oocyte pick-up (OPU) proced…

Female reproductive disorders influence women's physical and mental well-being, and the sustainability of the family. However, it is unclear whether lifestyle factors, including sedentary behaviors and physical activity, could impact them. …

Endometriosis (EMS) is characterised by a disrupted peritoneal immune microenvironment where M2 macrophage polarization and impaired phagocytosis promote lesion survival. Single-cell RNA-seq (ScRNAseq) of the peritoneal macrophages from EMS…

BACKGROUND: To assess and compare the efficiency and outcomes between prone split-leg position and lithotomy position in posterior uterine myomectomy by transvaginal natural orifice transluminal endoscopic surgery (vNOTES). METHODS: 33 pat…

BACKGROUND: The positive effects of dehydroepiandrosterone (DHEA) on oocyte and embryo quality improvement are often concerned. While the results on DHEA-induced endometrial improvement are controversial. OBJECTIVE: To evaluate whether DHE…

BACKGROUND: Pelvic floor surface electromyography (sEMG) is widely used to evaluate and treat pelvic floor dysfunctions (PFDs). Based on sEMG, the Glazer protocol was developed over 20 years ago with a limited sample size, making it challen…

Uterine arteriovenous malformation (UAVM) is a rare cause of vaginal bleeding in women of childbearing age. Due to the rarity of UAVM, previous studies have classified UAVM into primary and secondary types based on whether the uterus has be…

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder with unclear pathogenesis. Increasing evidence suggests that oxidative stress and mitochondrial dysfunction contribute to PCOS development. Sirtuins (SIRTs), esp…

BackgroundMethylenetetrahydrofolate reductase (MTHFR) regulates folate metabolism and homocysteine (Hcy) methylation. Impaired folate metabolism and vitamin D deficiency are both closely associated with female reproductive disorders, but th…

This study aims to explore the association between stress coping and primary dysmenorrhea among Chinese female adolescent students. A two-step random, stratified, cluster sampling method was employed to assess the health status of female ad…

BACKGROUND: The Cardiometabolic Index (CMI), a composite marker integrating lipid profiles (triglycerides-to-HDL-C ratio) and abdominal obesity (waist-to-height ratio), we aimed to assess its association with gallstone prevalence. METHODS:…

PURPOSE: Polycystic ovary syndrome (PCOS) is an endocrine syndrome that afflicts women of childbearing age, whose specific pathogenesis is unknown. Combined multiomics analysis on it is still lacking. The purpose of this study was to use co…