Peng PC

ORCID: 0000-0002-5004-4322 · 4 papers in corpus
other 2025
Characterizing somatic mutations in ovarian cancer germline risk regions
Communications biology ·doi:10.1038/s42003-025-08072-1

Epithelial ovarian cancer (EOC) genetics research has been focused on germline or somatic mutations independently. Emerging evidence suggests that the somatic mutational landscape can be shaped by the germline genetic background. In this st…

observational 2024
Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions
American journal of human genetics ·doi:10.1016/j.ajhg.2024.04.011

To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases an…

observational 2022
Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci
Journal of the National Cancer Institute ·doi:10.1093/jnci/djac160

BACKGROUND: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort. METHODS:…

other 2020
Ovarian Cancer Risk Variants Are Enriched in Histotype-Specific Enhancers and Disrupt Transcription Factor Binding Sites
American journal of human genetics ·doi:10.1016/j.ajhg.2020.08.021

Quantifying the functional effects of complex disease risk variants can provide insights into mechanisms underlying disease biology. Genome-wide association studies have identified 39 regions associated with risk of epithelial ovarian cance…