Renato Seracchioli

STUDY OBJECTIVE: This study investigated whether quantitative analysis of preoperative magnetic resonance imaging (MRI) scans can differentiate deep infiltrating endometriosis (DIE) lesion types (active or fibrotic lesion [FL]) and associat…

OBJECTIVE: To investigate the association between central sensitization inventory (CSI) scores/central sensitization (CS) and hormonal therapy failure (HTF) for endometriosis. DESIGN: Single-center, observational, prospective, cohort study…

BACKGROUND: Pain is the primary symptom of endometriosis and may progress into a chronic, acyclic condition driven by neuroinflammatory mechanisms, leading to neuropathic and ultimately nociplastic pain. Central sensitization, a form of noc…

Deep infiltrating endometriosis and oncologic radical pelvic surgeries pose a significant risk of nerve damage. A thorough understanding of pelvic anatomy is essential for surgical precision and to avoid neurological complications or dysfun…

Early-onset colorectal cancer is increasing, making reproductive health an increasingly relevant survivorship issue. While immune checkpoint inhibitors have altered the management of deficient mismatch repair/microsatellite instability-high…

OBJECTIVE: The primary objective of this study is to assess the impact of hysteroscopic metroplasty on symptom relief, including dysmenorrhea, dyspareunia, and menstrual blood flow in women with partial uterine septa (U2a class). Additional…

Background: Endometrial cancer (EC) is the most common gynecological malignancy in Western countries. Although international guidelines recommend that patients with EC be treated at specialized oncology centers, many are still managed by ge…

STUDY QUESTION: Are endometriotic lesions affecting bilateral organs or anatomical structures distributed symmetrically on both sides of the body? SUMMARY ANSWER: The left-sided preponderance of pelvic endometriotic lesions, and the right-…

OBJECTIVES: Adenomyosis is challenging to diagnose with transvaginal ultrasound (TVUS) and requires operator expertise to recognize its sonographic features; however, little is known about the learning curve for trainees. This study aimed t…

BACKGROUND: Robotic-assisted hysterectomy is increasingly performed using modular platforms such as the Hugo™ roboticassisted surgery (RAS) system, but optimal or personalised docking strategies remain undefined. OBJECTIVES: To establish e…

OBJECTIVE: This study aimed to evaluate the prevalence of urinary symptoms in women with parametrial endometriosis before and after surgery. DATA SOURCES: We systematically searched MEDLINE, Web of Science, and Scopus through March 2025, w…

OBJECTIVE: Endometriosis is linked to an increased risk of epithelial ovarian cancer (EOC), especially clear cell and endometrioid subtypes. The extent and prognostic significance of this link are still not fully understood. This systematic…

BACKGROUND: Urinary tract endometriosis affects fewer than 6% of patients with endometriosis, with ureteral involvement representing the second most common site of disease (9-23%). The condition is often asymptomatic, which may result in si…

INTRODUCTION: Seromucinous borderline ovarian tumors represent a distinct borderline ovarian tumor histotype, yet their specific sonographic features and clinical associations remain undercharacterized. The objective of this study was to de…

STUDY OBJECTIVE: To assess the diagnostic accuracy of different ultrasonographic features of uterosacral ligaments (USLs) affected by endometriosis. DESIGN: Multicentric, observational, prospective, diagnostic study. SETTING: Two tertiary…

OBJECTIVE: The AAGL 2021 classification assesses intraoperative surgical complexity using a four-stage scale based on lesion size and location. Despite its potential utility, no data currently assess its correlation with perioperative compl…

OBJECTIVE: To investigate the prevalence of various ultrasound morphologies of rectosigmoid endometriosis (RSE) nodules according to the International Deep Endometriosis Analysis consensus, and their potential association with distinct clin…

Linked article: There is a comment on this article by Moro et al. Click here to view the Correspondence.

BACKGROUND: Lower Anti-Müllerian hormone (AMH) levels have been observed in women with ovarian endometriomas (OMA) undergoing combined hormonal contraceptive (CHC) therapy. However, the extent and timing of AMH recovery after CHC discontinu…

OBJECTIVE: Bowel endometriosis affects 8% to 12% of women with infiltrating endometriosis, mostly involving the rectum and sigmoid [1]. Surgery is preferred when medical therapy fails or is contraindicated. Although segmental resection has …

INTRODUCTION: Long-acting reversible contraceptives (LARCs) are increasingly gaining popularity due to their high efficacy and ease of use compared to short-acting reversible contraceptives (SARCs). Among available LARCs, the etonogestrel (…

BACKGROUND: Accurate reporting of participants' race and ethnicity is essential for assessing the representativeness of study populations and for identifying potential disparities in diagnosis, treatment, and outcomes. OBJECTIVES: To asses…

This feasibility study explores the potential of salivary microRNAs (miRNAs) as non-invasive biomarkers for diagnosing endometriosis and assessing treatment response. Almost one-third of patients with endometriosis do not respond to the sta…