Lina Chen

ORCID: 0000-0002-2423-2418 · 4 papers in corpus
observational 2025
Microbiome analysis of the cystic fluid in ovarian endometrioma: new avenues for the prevention, diagnosis, and treatment of the disease
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-025-01511-y

OBJECTIVE: This study aimed to investigate the microbiome profile in the cystic fluid of ovarian endometrioma and explore its association with the microbial communities present in the lower and upper reproductive tracts. DESIGN: A microbia…

other 2024
Development of a machine learning-based prediction model for clinical pregnancy of intrauterine insemination in a large Chinese population
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-024-03153-2

PURPOSE: This study aimed to evaluate the effectiveness of a random forest (RF) model in predicting clinical pregnancy outcomes from intrauterine insemination (IUI) and identifying significant factors affecting IUI pregnancy in a large Chin…

lab-animal 2024
Iron overload increases the sensitivity of endometriosis stromal cells to ferroptosis via a PRC2-independent function of EZH2
The international journal of biochemistry & cell biology ·doi:10.1016/j.biocel.2024.106553

Given the high concentration of iron in the micro-environment of ovarian endometriosis, it is plausible to hypothesize that ectopic endometrial cells may be more susceptible to undergoing ferroptosis. Manipulation of ferroptosis has been ex…

other 2024
Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disorders
Biomarker research ·doi:10.1186/s40364-024-00598-6

BACKGROUND: Placenta accreta spectrum disorders (PAS) are a severe complication characterized by abnormal trophoblast invasion into the myometrium. The underlying mechanisms of PAS involve a complex interplay of various cell types and molec…