Tsutomu Ishikawa — Endo Lab

lab-animal 2000

Growth-stimulating effect of dienogest, a synthetic steroid, on rodent, canine, and primate mammary glands

Toxicology ·doi:10.1016/s0300-483x(00)00318-8

We observed hyperplasia of the mammary gland in female beagle dogs, but not in female rats and monkeys, in 91-day toxicity studies on dienogest. In order to elucidate a possible mechanism for its development and to account for this species …

lab-animal 1999

Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats

Toxicology letters ·doi:10.1016/s0378-4274(98)00354-3

We investigated the effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats compared with that of medroxyprogesterone acetate (MPA) and danazol, in order to elucidate the reason for relativel…

lab-animal 1998

Effects of dienogest (a synthetic steroid) on coagulation, fibrinolysis, and platelet aggregation in female monkeys

Toxicology letters ·doi:10.1016/s0378-4274(98)00109-x

We investigated the effects of dienogest (0.1-10 mg/kg per day, p.o.) on coagulation, fibrinolysis and platelet aggregation in female rhesus monkeys. Then, we also examined those of medroxyprogesterone acetate (MPA, 10 mg/kg per day, p.o.) …