Emmanouíl Karteris

other 2026

Integrative mRNA and miRNA Profiling Identifies Shared and Subtype-Associated PI3K-AKT-mTOR Pathway Dysregulation and Candidate miRNA-Mediated Regulatory Interactions in Endometriosis-Associated Ovarian Cancers (EAOCs)

Biomedicines ·doi:10.3390/biomedicines14091991

Background: Endometriosis-associated ovarian cancers (EAOCs), including ovarian clear cell (OCCC) and endometrioid ovarian carcinoma (EnOC) subtypes, frequently exhibit transcriptomic dysregulation of the PI3K/AKT/mTOR signalling axis. Whil…

2026

MicroRNA-Mediated Rewiring of the PI3K–AKT–mTOR Axis Reveals Divergent Regulatory Networks and Metabolic Vulnerabilities in Endometriosis-Associated Ovarian Cancers (EAOCs)

·doi:10.20944/preprints202607.1410.v1

Background: Endometriosis-associated ovarian cancers (EAOCs), including clear cell (OCCC) and endometrioid (EnOC) subtypes, frequently activate the PI3K/AKT/mTOR signaling axis. While genomic aberrations are well documented, the coordinate…

review 2024

The "Road" to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review

Cancers ·doi:10.3390/cancers16112160

Ovarian cancer is an umbrella term covering a number of distinct subtypes. Endometrioid and clear-cell ovarian carcinoma are endometriosis-associated ovarian cancers (EAOCs) frequently arising from ectopic endometrium in the ovary. The mech…

lab-animal 2018

Differential expression of mTOR components in endometriosis and ovarian cancer: Effects of rapalogues and dual kinase inhibitors on mTORC1 and mTORC2 stoichiometry

International journal of molecular medicine ·doi:10.3892/ijmm.2018.3967

Endometriosis is a well‑known risk factor for ovarian cancer. The genetic changes that characterise endometriosis are poorly understood; however, the mechanistic target of rapamycin (mTOR) pathway is involved. In this study, we investigated…

case-report 2009

Congenital imperforate hymen with hydrocolpos and hydronephrosis associated with severe hydramnios and increase of maternal ovarian steroidogenic enzymes

Journal of Pediatric and Adolescent Gynecology ·doi:10.1016/j.jpag.2009.10.002

STUDY OBJECTIVE: To study clinical features of patient presented with severe hydramnios, associated with hydronephrosis, that was antenatally diagnosed and has been successfully treated immediately after birth. At a molecular level, we inve…

other 2003

The Glu298-->Asp polymorphism of the endothelial nitric oxide synthase gene is associated with endometriosis

Fertility and sterility ·doi:10.1016/s0015-0282(03)02204-0