Gaizhen Li

No ORCID on file · 3 papers in corpus
lab-animal 2025
WT1 directs normal progesterone receptor-chromatin binding essential for uterine receptivity at peri-implantation
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2504361122

Progesterone receptor (PR)-mediated progesterone (P4) signaling plays a crucial role in the establishment of uterine receptivity which is the prerequisite for successful embryo implantation in mammals. However, detailed molecular mechanisms…

lab-animal 2023
CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis
Nature communications ·doi:10.1038/s41467-023-39008-0

Progesterone (P4) is required for the preparation of the endometrium for a successful pregnancy. P4 resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to infertility; however, the un…

lab-animal 2022
P38α MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2206000119

Estrogen and progesterone specify the establishment of uterine receptivity mainly through their respective nuclear receptors, ER and PR. PR is transcriptionally induced by estrogen-ER signaling in the endometrium, but how the protein homeos…