Mathias RT

No ORCID on file · 2 papers in corpus

lab-animal 2014

Autocrine A2 in the T-system of ventricular myocytes creates transmural gradients in ion transport: a mechanism to match contraction with load?

Biophysical journal ·doi:10.1016/j.bpj.2014.04.042

Transmural heterogeneities in Na/K pump current (IP), transient outward K(+)-current (Ito), and Ca(2+)-current (ICaL) play an important role in regulating electrical and contractile activities in the ventricular myocardium. Prior studies in…

lab-animal 2005

Transmural gradients in Na/K pump activity and [Na+]I in canine ventricle

Biophysical journal ·doi:10.1529/biophysj.105.062406

There are well-documented differences in ion channel activity and action potential shape between epicardial (EPI), midmyocardial (MID), and endocardial (ENDO) ventricular myocytes. The purpose of this study was to determine if differences e…