Davis JW

No ORCID on file · 4 papers in corpus
meta-analysis 2022
The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases
BMC medical genomics ·doi:10.1186/s12920-022-01216-w

BACKGROUND: The remarkable growth of genome-wide association studies (GWAS) has created a critical need to experimentally validate the disease-associated variants, 90% of which involve non-coding variants. METHODS: To determine how the fie…

lab-animal 2013
Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first-generation and second-generation embryos
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.07.007

OBJECTIVE: To characterize multigenerational gene expression anomalies in eight-cell stage embryos associated with developmental exposure to endometriosis. DESIGN: Using an endometriosis model in rats (F0 founder generation) to evaluate ge…

lab-animal 2010
Inflammatory cytokines differentially up-regulate human endometrial haptoglobin production in women with endometriosis
Human Reproduction ·doi:10.1093/humrep/deq032

BACKGROUND: Evidence suggests that eutopic endometrium from women with endometriosis (US-E) has intrinsic functional anomalies compared with women without endometriosis (US-C). We hypothesized that differences in endometrial haptoglobin (eH…

lab-animal 2009
Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.03.086

OBJECTIVE: To define the altered gene expression profile of endometriotic lesions in a mouse model of surgically induced endometriosis. DESIGN: Autologous experimental mouse model. SETTING: Medical school department. ANIMAL(S): Adult C57…